TY - JOUR
T1 - Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice
AU - Chen, Kun Ming
AU - Schell, Todd D.
AU - Richie, John P.
AU - Sun, Yuan Wan
AU - Zhang, Shang Min
AU - Calcagnotto, Ana
AU - Aliaga, Cesar
AU - Gowda, Krishne
AU - Amin, Shantu
AU - El-Bayoumy, Karam
N1 - Publisher Copyright:
© 2017 Taylor & Francis Group, LLC.
PY - 2017/10/2
Y1 - 2017/10/2
N2 - Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (−)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.
AB - Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (−)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.
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U2 - 10.1080/10590501.2017.1391514
DO - 10.1080/10590501.2017.1391514
M3 - Article
C2 - 29106334
AN - SCOPUS:85036594634
SN - 1059-0501
VL - 35
SP - 213
EP - 222
JO - Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
JF - Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
IS - 4
ER -