Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice

Kun Ming Chen, Todd D. Schell, John P. Richie, Yuan Wan Sun, Shang Min Zhang, Ana Calcagnotto, Cesar Aliaga, Krishne Gowda, Shantu Amin, Karam El-Bayoumy

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (−)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalJournal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volume35
Issue number4
DOIs
StatePublished - Oct 2 2017

All Science Journal Classification (ASJC) codes

  • Health, Toxicology and Mutagenesis
  • Cancer Research

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