Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice

Kun Ming Chen; Todd D. Schell; John P. Richie; Yuan Wan Sun; Shang Min Zhang; Ana Calcagnotto; Cesar Aliaga; Krishne Gowda; Shantu Amin; Karam El-Bayoumy

doi:10.1080/10590501.2017.1391514

Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice

Kun Ming Chen
, Todd D. Schell
, John P. Richie
, Yuan Wan Sun
, Shang Min Zhang
, Ana Calcagnotto
, Cesar Aliaga
, Krishne Gowda
, Shantu Amin
, Karam El-Bayoumy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (−)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.

Original language	English (US)
Pages (from-to)	213-222
Number of pages	10
Journal	Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volume	35
Issue number	4
DOIs	https://doi.org/10.1080/10590501.2017.1391514
State	Published - Oct 2 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Health, Toxicology and Mutagenesis
Cancer Research

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10.1080/10590501.2017.1391514

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Chen, K. M., Schell, T. D., Richie, J. P., Sun, Y. W., Zhang, S. M., Calcagnotto, A., Aliaga, C., Gowda, K., Amin, S., & El-Bayoumy, K. (2017). Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice. Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, 35(4), 213-222. https://doi.org/10.1080/10590501.2017.1391514

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title = "Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice",

abstract = "Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4\% v/v in the diet, 35\% of Calories) significantly enhanced the levels of (−)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.",

author = "Chen, \{Kun Ming\} and Schell, \{Todd D.\} and Richie, \{John P.\} and Sun, \{Yuan Wan\} and Zhang, \{Shang Min\} and Ana Calcagnotto and Cesar Aliaga and Krishne Gowda and Shantu Amin and Karam El-Bayoumy",

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Chen, KM , Schell, TD, Richie, JP, Sun, YW, Zhang, SM, Calcagnotto, A, Aliaga, C , Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice', Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 35, no. 4, pp. 213-222. https://doi.org/10.1080/10590501.2017.1391514

Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice. / Chen, Kun Ming ; Schell, Todd D.; Richie, John P. et al.
In: Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, Vol. 35, No. 4, 02.10.2017, p. 213-222.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice

AU - Chen, Kun Ming

AU - Schell, Todd D.

AU - Richie, John P.

AU - Sun, Yuan Wan

AU - Zhang, Shang Min

AU - Calcagnotto, Ana

AU - Aliaga, Cesar

AU - Gowda, Krishne

AU - Amin, Shantu

AU - El-Bayoumy, Karam

PY - 2017/10/2

Y1 - 2017/10/2

N2 - Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (−)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.

AB - Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (−)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.

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Chen KM , Schell TD, Richie JP, Sun YW, Zhang SM, Calcagnotto A et al. Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice. Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews. 2017 Oct 2;35(4):213-222. doi: 10.1080/10590501.2017.1391514

Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice

Abstract

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