Effects of dairy products on intracellular calcium and blood pressure in adults with essential hypertension

Kirsten F. Hilpert, Sheila G. West, Deborah M. Bagshaw, Valerie Fishell, Linda Barnhart, Michael Lefevre, Marlene M. Most, Michael B. Zemel, Mosuk Chow, Alan L. Hinderliter, Penny M. Kris-Etherton

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background: Consumption of dairy foods has been associated with lower blood pressure in certain populations. Objective: This study examined the effects of dairy foods on blood pressure (BP) and intracellular calcium ((Ca)i) and the dependence of BP changes on changes in (Ca)i. Design: Twenty-three stage 1 hypertensive adults were fed the following 3 experimental diets (5 wk each) in a randomized cross-over design study; a dairy-rich, high fruits and vegetables diet (D-F&V; 30% fat, 7% saturated fat (SFA), 3.4 servings/d dairy), a high fruits and vegetables diet (F&V; 30% fat, 7% SFA, 0.4 servings/d dairy), and an average Western diet (control; 36% fat, 15% SFA, 0.4 servings/d dairy). Systolic (SBP) and diastolic (DBP) BP, calcium regulatory hormones, and erythrocyte (Ca)i were determined. Results: SBP and DBP were significantly reduced by ∼2 mm Hg following both D-F&V and F&V diets vs. the control (P < 0.05). The D-F&V diet significantly lowered 1,25-dihydroxyvitaminD compared with the F&V and control diets (P < 0.01). Serum calcium, parathyroid hormone, calcitonin, and renin activity were unchanged. The D-F&V diet lowered (Ca)i vs. the other two diets (P < 0.01), and this change correlated with the fall in DBP (r = 0.52, P < 0.05). Subjects who responded to the D-F&V diet by significantly reducing (Ca)i exhibited significantly greater net decreases in DBP on the D-F&V vs. the F&V (−2.8 ± 1.0 mm Hg) and control diets (−5.4 ±1.0 mm Hg; diet × group interaction, P < 0.02). Conclusion: Consumption of dairy foods beneficially affects (Ca)i, resulting in improved BP in a subgroup defined by (Ca)i response.

Original languageEnglish (US)
Pages (from-to)142-149
Number of pages8
JournalJournal of the American College of Nutrition
Issue number2
StatePublished - Apr 1 2009

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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