Effects of dopaminergic agonists and antagonists on cerebellar guanosine-3′, 5′-monophosphate (cGMP)

G. R. Breese; R. B. Mailman; M. G. Ondrusek; T. K. Harden; R. A. Mueller

doi:10.1016/0024-3205(78)90167-4

Effects of dopaminergic agonists and antagonists on cerebellar guanosine-3′, 5′-monophosphate (cGMP)

G. R. Breese, R. B. Mailman, M. G. Ondrusek, T. K. Harden, R. A. Mueller

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Apomorphine was found to cause an increase in cerebellar cGMP content. Bromocriptine, at a dose that caused stereotypies, neither elevated cGMP, nor blocked the apomorphine- induced rise in cGMP. The apomorphine-induced rise in cGMP was effectively blocked by haloperidol and some other neuroleptics, but not by sulpiride. These actions of the neuroleptics correlated with their ability to displace ³H-spiroperidol from striatal membranes, suggesting that dopamine receptor interactions were important in the cGMP changes noted. Based on the observation that haloperidol antagonized the increase induced by restraint, it is suggested that dopaminergic systems are involved in the reaction to stress.

Original language	English (US)
Pages (from-to)	533-536
Number of pages	4
Journal	Life Sciences
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(78)90167-4
State	Published - Aug 7 1978

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(78)90167-4

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@article{55b8a6c7294e496c9678000841098c2c,

title = "Effects of dopaminergic agonists and antagonists on cerebellar guanosine-3′, 5′-monophosphate (cGMP)",

abstract = "Apomorphine was found to cause an increase in cerebellar cGMP content. Bromocriptine, at a dose that caused stereotypies, neither elevated cGMP, nor blocked the apomorphine- induced rise in cGMP. The apomorphine-induced rise in cGMP was effectively blocked by haloperidol and some other neuroleptics, but not by sulpiride. These actions of the neuroleptics correlated with their ability to displace 3H-spiroperidol from striatal membranes, suggesting that dopamine receptor interactions were important in the cGMP changes noted. Based on the observation that haloperidol antagonized the increase induced by restraint, it is suggested that dopaminergic systems are involved in the reaction to stress.",

author = "Breese, {G. R.} and Mailman, {R. B.} and Ondrusek, {M. G.} and Harden, {T. K.} and Mueller, {R. A.}",

note = "Funding Information: The authors note the invaluable assistance of D. Smith, E. Hoke, C. Jones, and M. Handschy. This work was supported in part by U.S.PH.S. grants HD-I0570, ES-OII04, MH-O0013,a nd MH-25573. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1978",

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doi = "10.1016/0024-3205(78)90167-4",

language = "English (US)",

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pages = "533--536",

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T1 - Effects of dopaminergic agonists and antagonists on cerebellar guanosine-3′, 5′-monophosphate (cGMP)

AU - Breese, G. R.

AU - Mailman, R. B.

AU - Ondrusek, M. G.

AU - Harden, T. K.

AU - Mueller, R. A.

N1 - Funding Information: The authors note the invaluable assistance of D. Smith, E. Hoke, C. Jones, and M. Handschy. This work was supported in part by U.S.PH.S. grants HD-I0570, ES-OII04, MH-O0013,a nd MH-25573. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1978/8/7

Y1 - 1978/8/7

N2 - Apomorphine was found to cause an increase in cerebellar cGMP content. Bromocriptine, at a dose that caused stereotypies, neither elevated cGMP, nor blocked the apomorphine- induced rise in cGMP. The apomorphine-induced rise in cGMP was effectively blocked by haloperidol and some other neuroleptics, but not by sulpiride. These actions of the neuroleptics correlated with their ability to displace 3H-spiroperidol from striatal membranes, suggesting that dopamine receptor interactions were important in the cGMP changes noted. Based on the observation that haloperidol antagonized the increase induced by restraint, it is suggested that dopaminergic systems are involved in the reaction to stress.

AB - Apomorphine was found to cause an increase in cerebellar cGMP content. Bromocriptine, at a dose that caused stereotypies, neither elevated cGMP, nor blocked the apomorphine- induced rise in cGMP. The apomorphine-induced rise in cGMP was effectively blocked by haloperidol and some other neuroleptics, but not by sulpiride. These actions of the neuroleptics correlated with their ability to displace 3H-spiroperidol from striatal membranes, suggesting that dopamine receptor interactions were important in the cGMP changes noted. Based on the observation that haloperidol antagonized the increase induced by restraint, it is suggested that dopaminergic systems are involved in the reaction to stress.

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DO - 10.1016/0024-3205(78)90167-4

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AN - SCOPUS:0018146091

SN - 0024-3205

VL - 23

SP - 533

EP - 536

JO - Life Sciences

JF - Life Sciences

IS - 5

ER -

Effects of dopaminergic agonists and antagonists on cerebellar guanosine-3′, 5′-monophosphate (cGMP)

Abstract

All Science Journal Classification (ASJC) codes

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