TY - JOUR
T1 - Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes
AU - Liu, Henry
AU - Sangkum, Lisa
AU - Liu, Geoffrey
AU - Green, Michael
AU - Li, Marilyn
AU - Kaye, Alan
N1 - Publisher Copyright:
© 2016 by the Journal of Biomedical Research. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Epinephrine is often used for the treatment of patients with heart failure, low cardiac output and cardiac arrest. It can acutely improve hemodynamic parameters; however, it does not seem to improve longer term clinical outcomes. Therefore, we hypothesized that epinephrine may induce unfavorable changes in gene expression of cardiomyocyte. Thus, we investigated effects of epinephrine exposure on the mediation or modulation of gene expression of cultured cardiomyocytes at a genome-wide scale. Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression of angiopoietin-2 gene (+2.1 times), and down-regulate the gene expression of neuregulin 1 (-3.7 times), plasminogen activator inhibitor-1 ( -2.4 times) and SPARC-related modular calcium-binding protein-2 (-4.5 times). These changes suggest that epinephrine exposure may induce inhibition of angiogenesis-related gene expressions in cultured rat cardiomyocytes. The precise clinical significance of these changes in gene expression, which was induced by epinephrine exposure, warrants further experimental and clinical investigations.
AB - Epinephrine is often used for the treatment of patients with heart failure, low cardiac output and cardiac arrest. It can acutely improve hemodynamic parameters; however, it does not seem to improve longer term clinical outcomes. Therefore, we hypothesized that epinephrine may induce unfavorable changes in gene expression of cardiomyocyte. Thus, we investigated effects of epinephrine exposure on the mediation or modulation of gene expression of cultured cardiomyocytes at a genome-wide scale. Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression of angiopoietin-2 gene (+2.1 times), and down-regulate the gene expression of neuregulin 1 (-3.7 times), plasminogen activator inhibitor-1 ( -2.4 times) and SPARC-related modular calcium-binding protein-2 (-4.5 times). These changes suggest that epinephrine exposure may induce inhibition of angiogenesis-related gene expressions in cultured rat cardiomyocytes. The precise clinical significance of these changes in gene expression, which was induced by epinephrine exposure, warrants further experimental and clinical investigations.
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U2 - 10.7555/JBR.30.20160024
DO - 10.7555/JBR.30.20160024
M3 - Article
AN - SCOPUS:84992463250
SN - 1674-8301
VL - 30
SP - 380
EP - 385
JO - Journal of Biomedical Research
JF - Journal of Biomedical Research
IS - 5
ER -