@article{b3368d0f44704ee09da94476f76e1765,
title = "Effects of feeding, fasting and refeeding on growth hormone and insulin in obese pigs",
abstract = "This study has indicated that temporal patterns of plasma GH changes were similar in lean and obese pigs with one to two secretory spikes occurring during a 6-hour period. Fasting caused increased GH in both pig strains; however, obese pigs, compared to lean, had lower GH during feeding and fasting. This depressed plasma GH of obese pigs may not be due entirely to impaired pituitary function since refeeding caused increased GH to levels similar to lean pigs. Insulin response per unit of feed intake was greater in obese pigs compared to lean. Together with higher insulin to glucose ratios, these results indicate hyperinsulinemia in the obese pigs. Overall, hormone and glucose responses were influenced by the nutritive status-fed, fasted or refed. Therefore consideration of feeding schedule was important in assessment of hormonal differences between the lean and obese pigs.",
author = "McCusker, {R. H.} and Wangsness, {P. J.} and Griel, {L. C.} and Kavanaugh, {J. F.}",
note = "Funding Information: Six female obese (Ossabaw) pigs, 25 kg BW, and six female lean (Yorkshire) pigs, 37 kg BW, approximately 100 day of age were used. Animals were surgically prepared with an indwelling aortic catheter inserted via the femoral artery, exteriorized onto the back and attached to a protective canvas back-pack \[30\].S urgery was performed 3 to 4 days prior to the first experiment. An extension catheter was used to facilitate blood sampling with minimal disturbance to the animals. Pigs were housed in individual plywood pens at The Pennsylvania State University Animal Maintenance Center; pens were adjacent so pigs could see, hear and smell other pigs. A standard corn and soybean ration containing 14 per- 1Authorized for publication as paper No. 6831 in the journal series of the Pennsylvania Agricultural Experiment Station and supported in part by NIH Grant HD 11121 to PJW. ~Requests for reprints should be addressed to Paul J. Wangsness, Department of Dairy and Animal Science, 324 Henning Building, University Park, PA 16802.",
year = "1985",
month = sep,
doi = "10.1016/0031-9384(85)90313-0",
language = "English (US)",
volume = "35",
pages = "383--388",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "3",
}