TY - JOUR
T1 - Effects of ghost red blood cells on tumor cell adhesion in shear flow
AU - Fu, Yi
AU - Wu, Jie
AU - Sun, Ren
AU - Ding, Zu Rong
AU - Dong, Cheng
N1 - Publisher Copyright:
Copyright © 2015 by the Editorial Board of Journal of Medical Biomechanics.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objective: To study the effect of ghost red blood cells (GRBCs) on white blood cell (WBC)-mediated adhesion of tumor cells (TCs) on endothelial cells (ECs) in shear flow. Methods: GRBCs with hematocrit (Hct) of 20% were added in the parallel plate flow chamber to observe changes in the number of tethered WBCs on ECs, the collision between TCs and adhesive WBCs, and the number of firmly adhered TCs at different shear rates of 62.5, 100, 200 s-1, respectively. Results: GRBCs could increase the number of adhered WBCs on ECs and the collision between TCs and adhesive WBCs, and finally enhance the adhesion of TCs on ECs, especially at high shear rate (200 s-1). However, the adhesion efficiency of TCs was not significantly influenced by GRBCs. Conclusions: GRBCs in shear flow can promote TC adhesion on ECs, and the research finding will provide a theoretical basis for cancer therapy.
AB - Objective: To study the effect of ghost red blood cells (GRBCs) on white blood cell (WBC)-mediated adhesion of tumor cells (TCs) on endothelial cells (ECs) in shear flow. Methods: GRBCs with hematocrit (Hct) of 20% were added in the parallel plate flow chamber to observe changes in the number of tethered WBCs on ECs, the collision between TCs and adhesive WBCs, and the number of firmly adhered TCs at different shear rates of 62.5, 100, 200 s-1, respectively. Results: GRBCs could increase the number of adhered WBCs on ECs and the collision between TCs and adhesive WBCs, and finally enhance the adhesion of TCs on ECs, especially at high shear rate (200 s-1). However, the adhesion efficiency of TCs was not significantly influenced by GRBCs. Conclusions: GRBCs in shear flow can promote TC adhesion on ECs, and the research finding will provide a theoretical basis for cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=84935126201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84935126201&partnerID=8YFLogxK
U2 - 10.3871/j.1004-7220.2015.02.099
DO - 10.3871/j.1004-7220.2015.02.099
M3 - Article
AN - SCOPUS:84935126201
SN - 1004-7220
VL - 30
SP - 99
EP - 103
JO - Yiyong Shengwu Lixue/Journal of Medical Biomechanics
JF - Yiyong Shengwu Lixue/Journal of Medical Biomechanics
IS - 2
ER -
