Effects of heroin and methadone on plasma cortisol and testosterone

J. H. Mendelson, R. E. Meyer, J. Ellingboe, S. M. Mirin, M. McDougle

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106 Scopus citations


Narcotic addicts self administered heroin intravenously for 10 days under controlled research ward conditions and were subsequently detoxified with methadone for 7 days. Plasma testosterone levels decreased significantly when heroin dosage was between 45 and 65 mg/day contrasted to predrug base line levels. Testosterone levels remained depressed during methadone withdrawal. No statistically significant changes in A.M. plasma cortisol levels were observed during both heroin acquisition and methadone withdrawal.

Original languageEnglish (US)
Pages (from-to)296-302
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Issue number2
StatePublished - Dec 1 1975

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology


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