Effects of high altitude and water deprivation on arginine vasopressin release in men

C. M. Maresh, W. J. Kraemer, D. A. Judelson, J. L. VanHeest, L. Trad, J. M. Kulikowich, K. L. Goetz, A. Cymerman, A. J. Hamilton

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21 Scopus citations


High-altitude exposure changes the distribution of body water and electrolytes. Arginine vasopressin (AVP) may influence these alterations. The purpose of this study was to examine the effect of a 24-h water deprivation trial (WDT) on AVP release after differing altitude exposures. Seven healthy males (age 22 ± 1 yr, height 176 ± 2 cm, mass 75.3 ± 1.8 kg) completed three WDTs: at sea level (SL), after acute altitude exposure (2 days) to 4,300 m (AA), and after prolonged altitude exposure (20 days) to 4,300 m (PA). Body mass, standing and supine blood pressures, plasma osmolality (Posm), and plasma AVP (PAVP) were measured at 0, 12, 16, and 24 h of each WDT. Urine volume was measured at each void throughout testing. Baseline Posm increased from SL to altitude (SL 291.7 ± 0.8 mosmol/kgH2O, AA 299.6 ± 2.2 mosmol/kgH2O, PA 302. 3 ± 1.5 mosmol/kgH20, P < 0.05); however, baseline PAVP measurements were similar. Despite similar Posm values, the maximal PAvP response during the WDT (at 16 h) was greater at altitude than at SL (SL 1.7 ± 0.5 pg/ml, AA 6.4 ± 0.7 pg/ml, PA 8.7 ± 0. 9 pg/ml, P < 0.05). In conclusion, hypoxia appeared to alter AVP regulation by raising the osmotic threshold and increasing AVP responsiveness above that threshold.

Original languageEnglish (US)
Pages (from-to)E20-E24
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number1 49-1
StatePublished - Jan 2004

All Science Journal Classification (ASJC) codes

  • General Medicine


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