Abstract
Objective: To observe the effects of lysophosphatidic acid (LPA) on arrhythmia in acute myocardial infarction (AMI) rats. Methods: AMI mode ls were prepared by ligating the left coronary branch of rats. 60 Wistar rats were divided into 5 groups: sham-operated (SO), AMI, AMI + LPA, AMI + pertussis toxin (PTX) and AMI+PTX+LPA. ECG were recorded, HR and VPBs were observed as important indexes. Results: Inci dence of tachycardia and VPBs of unit time in AMI group were increased compared with sham-operated group (P<0.01). Incidence of tachycardia and VPBs of unit time in AMI+LPA group were increased compared with AMI group (P<0.05). Incidence of tachycardia and VPBs of unit time in AMI+PTX group were decreased compared with AMI+ LPA group, it showed the effect was blocked by PTX, a G-protein-coupled receptor blocking agent. Conclusion: LPA can promote the occurrence of arrhythmi a in AMI rats.
Original language | English (US) |
---|---|
Pages (from-to) | 407-409 |
Number of pages | 3 |
Journal | Journal of Jilin University Medicine Edition |
Volume | 32 |
Issue number | 3 |
State | Published - May 1 2006 |
All Science Journal Classification (ASJC) codes
- Pharmacology