Effects of lysophosphatidic acid on arrhythmia in acute myocardial infarction rats

Xuexin Zhang; Chun Yan Zhao; Hong Zhang; Hong Wang; Ya Qin Sun; Guo Gan Zhong

Effects of lysophosphatidic acid on arrhythmia in acute myocardial infarction rats

Xuexin Zhang
, Chun Yan Zhao
, Hong Zhang
, Hong Wang
, Ya Qin Sun
, Guo Gan Zhong

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To observe the effects of lysophosphatidic acid (LPA) on arrhythmia in acute myocardial infarction (AMI) rats. Methods: AMI mode ls were prepared by ligating the left coronary branch of rats. 60 Wistar rats were divided into 5 groups: sham-operated (SO), AMI, AMI + LPA, AMI + pertussis toxin (PTX) and AMI+PTX+LPA. ECG were recorded, HR and VPBs were observed as important indexes. Results: Inci dence of tachycardia and VPBs of unit time in AMI group were increased compared with sham-operated group (P<0.01). Incidence of tachycardia and VPBs of unit time in AMI+LPA group were increased compared with AMI group (P<0.05). Incidence of tachycardia and VPBs of unit time in AMI+PTX group were decreased compared with AMI+ LPA group, it showed the effect was blocked by PTX, a G-protein-coupled receptor blocking agent. Conclusion: LPA can promote the occurrence of arrhythmi a in AMI rats.

Original language	English (US)
Pages (from-to)	407-409
Number of pages	3
Journal	Journal of Jilin University Medicine Edition
Volume	32
Issue number	3
State	Published - May 1 2006

All Science Journal Classification (ASJC) codes

Pharmacology

Cite this

@article{258864935c0644f2b44d7bf6cd866779,

title = "Effects of lysophosphatidic acid on arrhythmia in acute myocardial infarction rats",

abstract = "Objective: To observe the effects of lysophosphatidic acid (LPA) on arrhythmia in acute myocardial infarction (AMI) rats. Methods: AMI mode ls were prepared by ligating the left coronary branch of rats. 60 Wistar rats were divided into 5 groups: sham-operated (SO), AMI, AMI + LPA, AMI + pertussis toxin (PTX) and AMI+PTX+LPA. ECG were recorded, HR and VPBs were observed as important indexes. Results: Inci dence of tachycardia and VPBs of unit time in AMI group were increased compared with sham-operated group (P<0.01). Incidence of tachycardia and VPBs of unit time in AMI+LPA group were increased compared with AMI group (P<0.05). Incidence of tachycardia and VPBs of unit time in AMI+PTX group were decreased compared with AMI+ LPA group, it showed the effect was blocked by PTX, a G-protein-coupled receptor blocking agent. Conclusion: LPA can promote the occurrence of arrhythmi a in AMI rats.",

author = "Xuexin Zhang and Zhao, \{Chun Yan\} and Hong Zhang and Hong Wang and Sun, \{Ya Qin\} and Zhong, \{Guo Gan\}",

year = "2006",

month = may,

day = "1",

language = "English (US)",

volume = "32",

pages = "407--409",

journal = "Journal of Jilin University Medicine Edition",

issn = "1671-587X",

publisher = "Editorial Board of Jilin University",

number = "3",

}

TY - JOUR

T1 - Effects of lysophosphatidic acid on arrhythmia in acute myocardial infarction rats

AU - Zhang, Xuexin

AU - Zhao, Chun Yan

AU - Zhang, Hong

AU - Wang, Hong

AU - Sun, Ya Qin

AU - Zhong, Guo Gan

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Objective: To observe the effects of lysophosphatidic acid (LPA) on arrhythmia in acute myocardial infarction (AMI) rats. Methods: AMI mode ls were prepared by ligating the left coronary branch of rats. 60 Wistar rats were divided into 5 groups: sham-operated (SO), AMI, AMI + LPA, AMI + pertussis toxin (PTX) and AMI+PTX+LPA. ECG were recorded, HR and VPBs were observed as important indexes. Results: Inci dence of tachycardia and VPBs of unit time in AMI group were increased compared with sham-operated group (P<0.01). Incidence of tachycardia and VPBs of unit time in AMI+LPA group were increased compared with AMI group (P<0.05). Incidence of tachycardia and VPBs of unit time in AMI+PTX group were decreased compared with AMI+ LPA group, it showed the effect was blocked by PTX, a G-protein-coupled receptor blocking agent. Conclusion: LPA can promote the occurrence of arrhythmi a in AMI rats.

AB - Objective: To observe the effects of lysophosphatidic acid (LPA) on arrhythmia in acute myocardial infarction (AMI) rats. Methods: AMI mode ls were prepared by ligating the left coronary branch of rats. 60 Wistar rats were divided into 5 groups: sham-operated (SO), AMI, AMI + LPA, AMI + pertussis toxin (PTX) and AMI+PTX+LPA. ECG were recorded, HR and VPBs were observed as important indexes. Results: Inci dence of tachycardia and VPBs of unit time in AMI group were increased compared with sham-operated group (P<0.01). Incidence of tachycardia and VPBs of unit time in AMI+LPA group were increased compared with AMI group (P<0.05). Incidence of tachycardia and VPBs of unit time in AMI+PTX group were decreased compared with AMI+ LPA group, it showed the effect was blocked by PTX, a G-protein-coupled receptor blocking agent. Conclusion: LPA can promote the occurrence of arrhythmi a in AMI rats.

UR - https://www.scopus.com/pages/publications/33745155781

UR - https://www.scopus.com/pages/publications/33745155781#tab=citedBy

M3 - Article

AN - SCOPUS:33745155781

SN - 1671-587X

VL - 32

SP - 407

EP - 409

JO - Journal of Jilin University Medicine Edition

JF - Journal of Jilin University Medicine Edition

IS - 3

ER -

Effects of lysophosphatidic acid on arrhythmia in acute myocardial infarction rats

Abstract

All Science Journal Classification (ASJC) codes

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