TY - JOUR
T1 - Effects of malnutrition on long-term survival in adult patients after elective cardiac surgery
AU - Efremov, Sergey M.
AU - Ionova, Tatiana I.
AU - Nikitina, Tatiana P.
AU - Vedernikov, Pavel E.
AU - Dzhumatov, Timur A.
AU - Ovchinnikov, Timofey S.
AU - Rashidov, Abduvahhob A.
AU - Stoppe, Christian
AU - Heyland, Daren K.
AU - Lomivorotov, Vladimir V.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/3
Y1 - 2021/3
N2 - Objectives: The aim of this study was to investigate the relationship between malnutrition and long-term survival in patients who underwent cardiopulmonary bypass (CPB). Methods: This study analyzed the long-term survival data of a mixed cohort of 1187 cardiac patients previously enrolled in a prospective observational study of nutritional screening in cardiac surgery. Nutritional status was assessed using the Malnutrition Universal Screening Tool (MUST). The mean age of patients was 58.86 ± 10.07 y (95% confidence interval [CI], 58.2–59.4). The median time of follow-up was 73.4 mo (25th–75th percentiles, 18.3–101.3). Results: In all, 449 patients (37.8%) were lost to follow-up after hospitalization. For the remaining participants, the overall 8-y survival was 68% (95% CI, 59–76) and 77% (95% CI, 73–80; log-rank, P = 0.12) in patients with and without malnutrition risk, respectively. Statistically significant differences in survival were found during the 3-y follow-up of patients with heart valve disease: 83% (95% CI, 74–92) with malnutrition versus 93% (95% CI, 90–96) without malnutrition (log-rank, P = 0.03). The final multivariate Cox regression model revealed logistic EuroSCORE (hazard ratio (HR), 1.337; 95% CI, 1.110–1.612), cardiopulmonary bypass time <110.5 min (HR 0.463, 95% CI 0.255–0.842), preoperative albumin (HR 0.799, 95% CI 0.691–0.924), and C-reactive protein (HR, 1.106; 95% CI, 1.018–1.202) as independent predictors of 3-y survival. Conclusion: Preoperative malnutrition is not associated with 8-y mortality in a mixed cardiac surgery cohort. However, it may be associated with worse 3-y outcomes in patients with heart valve disease.
AB - Objectives: The aim of this study was to investigate the relationship between malnutrition and long-term survival in patients who underwent cardiopulmonary bypass (CPB). Methods: This study analyzed the long-term survival data of a mixed cohort of 1187 cardiac patients previously enrolled in a prospective observational study of nutritional screening in cardiac surgery. Nutritional status was assessed using the Malnutrition Universal Screening Tool (MUST). The mean age of patients was 58.86 ± 10.07 y (95% confidence interval [CI], 58.2–59.4). The median time of follow-up was 73.4 mo (25th–75th percentiles, 18.3–101.3). Results: In all, 449 patients (37.8%) were lost to follow-up after hospitalization. For the remaining participants, the overall 8-y survival was 68% (95% CI, 59–76) and 77% (95% CI, 73–80; log-rank, P = 0.12) in patients with and without malnutrition risk, respectively. Statistically significant differences in survival were found during the 3-y follow-up of patients with heart valve disease: 83% (95% CI, 74–92) with malnutrition versus 93% (95% CI, 90–96) without malnutrition (log-rank, P = 0.03). The final multivariate Cox regression model revealed logistic EuroSCORE (hazard ratio (HR), 1.337; 95% CI, 1.110–1.612), cardiopulmonary bypass time <110.5 min (HR 0.463, 95% CI 0.255–0.842), preoperative albumin (HR 0.799, 95% CI 0.691–0.924), and C-reactive protein (HR, 1.106; 95% CI, 1.018–1.202) as independent predictors of 3-y survival. Conclusion: Preoperative malnutrition is not associated with 8-y mortality in a mixed cardiac surgery cohort. However, it may be associated with worse 3-y outcomes in patients with heart valve disease.
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U2 - 10.1016/j.nut.2020.111057
DO - 10.1016/j.nut.2020.111057
M3 - Article
C2 - 33360035
AN - SCOPUS:85099511557
SN - 0899-9007
VL - 83
JO - Nutrition
JF - Nutrition
M1 - 111057
ER -
