Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: A pilot randomized double-blind study

Gwinnett Ladson; William Dodson; Stephanie D. Sweet; Anthony E. Archibong; Allen Kunselman; Laurence Demers; Peter Lee; Nancy Williams; Ponjola Coney; Richard Legro

doi:10.1016/j.fertnstert.2011.05.048

Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: A pilot randomized double-blind study

Gwinnett Ladson
, William Dodson
, Stephanie D. Sweet
, Anthony E. Archibong
, Allen Kunselman
, Laurence Demers
, Peter Lee
, Nancy Williams
, Ponjola Coney
, Richard Legro

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.

Original language	English (US)
Pages (from-to)	2595-2598.e6
Journal	Fertility and sterility
Volume	95
Issue number	8
DOIs	https://doi.org/10.1016/j.fertnstert.2011.05.048
State	Published - Jun 30 2011

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2011.05.048

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title = "Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: A pilot randomized double-blind study",

abstract = "Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.",

author = "Gwinnett Ladson and William Dodson and Sweet, \{Stephanie D.\} and Archibong, \{Anthony E.\} and Allen Kunselman and Laurence Demers and Peter Lee and Nancy Williams and Ponjola Coney and Richard Legro",

note = "Funding Information: Supported by PHS U54 HD044315 The Meharry Medical College/Penn State Cooperative Reproductive Science Center and a GCRC grant MO1 RR 10732 , and GCRC construction grant C06 RR016499 to Pennsylvania State University. ",

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T2 - A pilot randomized double-blind study

AU - Ladson, Gwinnett

AU - Dodson, William

AU - Sweet, Stephanie D.

AU - Archibong, Anthony E.

AU - Kunselman, Allen

AU - Demers, Laurence

AU - Lee, Peter

AU - Williams, Nancy

AU - Coney, Ponjola

AU - Legro, Richard

N1 - Funding Information: Supported by PHS U54 HD044315 The Meharry Medical College/Penn State Cooperative Reproductive Science Center and a GCRC grant MO1 RR 10732 , and GCRC construction grant C06 RR016499 to Pennsylvania State University.

PY - 2011/6/30

Y1 - 2011/6/30

N2 - Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.

AB - Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.

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UR - https://www.scopus.com/pages/publications/79959687822#tab=citedBy

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IS - 8

ER -

Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: A pilot randomized double-blind study

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