TY - JOUR
T1 - Effects of Moderate Aerobic Exercise Training on Vascular Health and Blood Pressure in African Americans
AU - Feairheller, Deborah L.
AU - Diaz, Keith M.
AU - Kashem, Mohammed A.
AU - Thakkar, Sunny R.
AU - Veerabhadrappa, Praveen
AU - Sturgeon, Kathleen M.
AU - Ling, Chenyi
AU - Williamson, Sheara T.
AU - Kretzschmar, Jan
AU - Lee, Hojun
AU - Grimm, Heather
AU - Babbitt, Dianne M.
AU - Vin, Charmie
AU - Fan, Xiaoxuan
AU - Crabbe, Deborah L.
AU - Brown, Michael D.
PY - 2014/7
Y1 - 2014/7
N2 - As healthcare progresses toward individualized medicine, understanding how different racial groups respond to lifestyle interventions is valuable. It is established that African Americans have disproportionate levels of cardiovascular disease and impaired vascular health, and clinical practice guidelines suggest lifestyle interventions as the first line of treatment. Recently, the authors reported that 6 months of aerobic exercise improved inflammatory markers, flow-mediated dilation (FMD), and levels of circulating endothelial microparticles (EMPs) in African American adults. This study is a subgroup analysis of the aerobic exercise-induced changes in vascular health and blood pressure (BP) measures, including carotid artery intima-media thickness (IMT), nitroglycerin-mediated dilation (NMD), ambulatory BP, and office BP. Sedentary African American adults (53.4±6.2 years; 21 women and 5 men) showed improved vascular health but no change in BP. Carotid artery IMT decreased 6.4%, plasma nitric oxide levels increased 76.6%, plasma EMP levels decreased, percentage of FMD increased 59.6%, and FMD/NMD ratio increased 36.2% (P<.05 for all). Six months of aerobic exercise training is sufficient to elicit improvements in vascular structure and function in African Americans, even without improvements in BP measures or NMD (ie, smooth muscle function). To our knowledge, this is the first study to report such findings in African Americans.
AB - As healthcare progresses toward individualized medicine, understanding how different racial groups respond to lifestyle interventions is valuable. It is established that African Americans have disproportionate levels of cardiovascular disease and impaired vascular health, and clinical practice guidelines suggest lifestyle interventions as the first line of treatment. Recently, the authors reported that 6 months of aerobic exercise improved inflammatory markers, flow-mediated dilation (FMD), and levels of circulating endothelial microparticles (EMPs) in African American adults. This study is a subgroup analysis of the aerobic exercise-induced changes in vascular health and blood pressure (BP) measures, including carotid artery intima-media thickness (IMT), nitroglycerin-mediated dilation (NMD), ambulatory BP, and office BP. Sedentary African American adults (53.4±6.2 years; 21 women and 5 men) showed improved vascular health but no change in BP. Carotid artery IMT decreased 6.4%, plasma nitric oxide levels increased 76.6%, plasma EMP levels decreased, percentage of FMD increased 59.6%, and FMD/NMD ratio increased 36.2% (P<.05 for all). Six months of aerobic exercise training is sufficient to elicit improvements in vascular structure and function in African Americans, even without improvements in BP measures or NMD (ie, smooth muscle function). To our knowledge, this is the first study to report such findings in African Americans.
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U2 - 10.1111/jch.12328
DO - 10.1111/jch.12328
M3 - Article
C2 - 24779748
AN - SCOPUS:84904043458
SN - 1524-6175
VL - 16
SP - 504
EP - 510
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 7
ER -