Abstract
1. The effect of opioid receptor blockade by naloxone in vivo on hepatic venous plasma glucose concentration in rats was investigated. 2. The plasma glucose levels in naloxone‐injected animals (10 mg/kg) were higher than in the control animals (P < 0.05). 3. At the lower dose of naloxone (2 mg/kg) the resulting plasma glucose concentration did not differ significantly from control (P > 0.1). 4. It is concluded that endogenous opioids may moderate the regulation of basal glucose levels in the rat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 911-913 |
| Number of pages | 3 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Volume | 14 |
| Issue number | 11-12 |
| DOIs | |
| State | Published - Dec 1987 |
All Science Journal Classification (ASJC) codes
- Physiology
- Pharmacology
- Physiology (medical)