Effects of ovariectomy in beagle dogs

R. B. Martin, R. L. Butcher, L. L. Sherwood, P. Buckendahl, R. D. Boyd, D. Farris, N. Sharkey, G. Dannucci

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Beagle dogs 3-7 years old were ovariectomized (n = 9) or sham operated (n = 6) and followed for 48 weeks with measurements of body weight, tibial shaft bone mineral content (BMC), and serum biochemistry. Following killing, measurements were made of bone strength and histomorphometry. Ovariectomy (OX) significantly reduced serum estrone and estradiol concentrations and their variability from month to month. There was a transient decrease in cortical BMC of the OX dogs during the first 12 postoperative weeks but no difference between the groups after 48 weeks. Serum osteocalcin was elevated, but there was little effect on serum alkaline phosphatase, Ca, P, or calcitonin. OX increased the number of tetracycline-labeled osteons in cortical bone but reduced the percent trabecular surface labeled with tetracycline. OX produced no significant changes in the composition of the bones or loss of cortical area, but a statistically significant 15% trabecular bone loss occurred in the spine. However, bone strength had not been significantly affected at the time of sacrifice.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
Issue number1
StatePublished - 1987

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Histology
  • Physiology


Dive into the research topics of 'Effects of ovariectomy in beagle dogs'. Together they form a unique fingerprint.

Cite this