Effects of peripherally administered GABA and other amino acids on cardiopulmonary responses in anesthetized rats and dogs

M. L. Billingsley, A. Suria

    Research output: Contribution to journalArticlepeer-review

    23 Scopus citations

    Abstract

    Intravenously administered GABA (1.0-1000 μg/kg) induced hypotension, bradycardia and tachypnea in both dogs and rats. The increased respiratory rate was not caused by changes in blood pH, pCO2, or pO2. None of the effects of GABA were modified by the following agents: propranolol, atropine, diphenhydramine, or hexamethonium. Taurine, glycine, β-alanine, glutamic acid and aspartic acid at doses of 1000 μg/kg, i.v., had no significant effects on any of the variables measured. Since these doses of GABA probably do not cross the blood-brain barrier, it is postulated that the observed effects of GABA may be due to direct actions on vascular, cardiac and lung tissue. The exact site of GABA action in the periphery remains to be elucidated.

    Original languageEnglish (US)
    Pages (from-to)131-140
    Number of pages10
    JournalArchives Internationales de Pharmacodynamie et de Therapie
    Volume255
    Issue number1
    StatePublished - 1982

    All Science Journal Classification (ASJC) codes

    • Pharmacology

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