Effects of standard and variant strains of infectious bursal disease virus on infections of chickens.

David Craft, J. Brown, P. D. Lukert

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


T-cell-mediated and humoral immune responses were measured in chickens infected with standard and variant strains of infectious bursal disease virus. One-day-old and 3-week-old chickens were infected with these viruses and then given sheep RBC, killed Brucella abortus strain 19, and Newcastle disease virus. Appropriate serologic tests were used to monitor the primary and secondary responses to the antigens. Lymphoblast transformation assays were performed weekly. The response to the infectious bursal disease virus was determined by virus neutralization tests, microscopic examination of bursas, and bursal to body weight ratios. One-day-old chickens had T-cell-mediated and humoral immune suppression with both strains of virus, compared with controls. The lymphoblast transformation responses indicated that the variant strain was significantly (P less than 0.05) more suppressive than the standard strain. Three-week-old chickens had humoral immune suppression with the standard strain, but not with the variant strain. The lymphoblast transformation response was transiently suppressed at this age by the variant strain only. During the first week of infection, 1-day-old and 3-week-old chickens had lower neutralizing antibody titers to the variant strain than to the standard strain.

Original languageEnglish (US)
Pages (from-to)1192-1197
Number of pages6
JournalAmerican Journal of Veterinary Research
Issue number8
StatePublished - Aug 1990

All Science Journal Classification (ASJC) codes

  • General Veterinary


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