TY - JOUR
T1 - Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults
AU - Flock, Michael R.
AU - Skulas-Ray, Ann C.
AU - Harris, William S.
AU - Gaugler, Trent L.
AU - Fleming, Jennifer A.
AU - Kris-Etherton, Penny M.
N1 - Funding Information:
We thank our research participants for their dedication to the project. We are also grateful to the nursing and clinician staff of the Clinical Research Center, part of The Pennsylvania State University Clinical and Translational Science Institute, which was supported by the National Center for Advancing Translational Sciences, National Institutes of Health , through Grant UL1TR000127 .
Funding Information:
This project was funded by a USDA, NIFA, Grant #2009–65200-05973 (P.M.K.E.). This research also was funded in part by an American Oil Chemists׳ Society Fellowship Award (M.R.F.) and a Baxter Pharmaceuticals Postdoctoral Fellowship (A.C.S.R.). This study was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, Grant UL1TR000127. The study protocol was approved by the Institutional Review Board at the Pennsylvania State University, and registered on ClinicalTrials.gov (NCT01078909). Study capsules were donated by Nordic Naturals, Inc., Watsonville, CA.
Publisher Copyright:
Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake (n=116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α (p<0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α (p=0.001); higher quartiles of arachidonic acid were associated with higher TNF-α (p=0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation.
AB - The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake (n=116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α (p<0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α (p=0.001); higher quartiles of arachidonic acid were associated with higher TNF-α (p=0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation.
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U2 - 10.1016/j.plefa.2014.07.006
DO - 10.1016/j.plefa.2014.07.006
M3 - Article
C2 - 25091379
AN - SCOPUS:85027955869
SN - 0952-3278
VL - 91
SP - 161
EP - 168
JO - Prostaglandins, leukotrienes, and essential fatty acids
JF - Prostaglandins, leukotrienes, and essential fatty acids
IS - 4
ER -