Effects of the synergist S,S,S-tributyl phosphorotrithioate on indoxacarb toxicity and metabolism in the European corn borer, Ostrinia nubilalis (Hübner)

Analiza P. Alves, William J. Allgeier, Blair D. Siegfried

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The toxicity of the oxadiazine insecticide indoxacarb to the European corn borer, Ostrinia nubilalis (Hübner) (Lepidoptera: Crambidae), was evaluated in the presence and absence of S,S,S-tributyl phosphorotrithioate (DEF), an inhibitor of hydrolytic metabolism. Bioassays involving topical application of different concentrations of indoxacarb to third instars of a susceptible O. nubilalis laboratory strain were performed, and in vitro metabolism experiments involving [14C] indoxacarb were examined to determine the role of hydrolytic metabolism in indoxacarb activation. Indoxacarb toxicity decreased in the presence of DEF indicating antagonism of toxicity. Results of in vivo and in vitro inhibition experiments indicated a reduction of indoxacarb activation and formation of the hydrolytic metabolite. These results are consistent with the proposed mechanism of hydrolytic activation for this compound.

Original languageEnglish (US)
Pages (from-to)26-30
Number of pages5
JournalPesticide Biochemistry and Physiology
Volume90
Issue number1
DOIs
StatePublished - Jan 2008

All Science Journal Classification (ASJC) codes

  • Agronomy and Crop Science
  • Health, Toxicology and Mutagenesis

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