Efficient synthesis of the anticancer drug etoposide 4′-phosphate: Use of benzylic ether-protecting groups on the carbohydrate segment

Keyphrases

• Carbohydrates 100%
• Phosphate 100%
• Anticancer Drugs 100%
• Etoposide 100%
• Protecting Groups 100%
• Benzylic Ethers 100%
• Efficient Synthesis 100%
• Crystallization 33%
• Prodrug 33%
• Steric Effect 33%
• Electronic Effect 33%
• Coupling Reaction 33%
• Benzyl Ethers 33%
• Anomerization 33%
• 4′-Demethylepipodophyllotoxin 33%
• Diastereoselective 33%
• Etoposide Phosphate 33%
• Easy Removal 33%
• Kilogram Scale 33%
• Overall Yield 33%
• Carbohydrate Components 33%

Chemistry

• Antineoplastic Agent 100%
• Protecting Groups 100%
• Etoposide 100%
• Steric Effect 50%
• Coupling Reaction 50%
• Etoposide Phosphate 50%
• Benzyl Ether 50%
• Prodrug 50%