Electrochemical Analysis in Picoliter Microvials

Rose A. Clark; Paula Beyer Hietpas; Andrew G. Ewing

doi:10.1021/ac960559a

Electrochemical Analysis in Picoliter Microvials

Rose A. Clark, Paula Beyer Hietpas, Andrew G. Ewing

Chemistry

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

Lithographically fabricated templates have been used to imprint picoliter to femtoliter microvials in polystyrene. The clear microvials produced in conjunction with a transmission optical microscope and micromanipulators make it possible to handle volumes as small as 1 pL. Voltammetry has been carried out in these well-defined microenvironments with restriction of reagents near the electrode surface. Ferrocenecarboxylic acid has been utilized to characterize the electrochemical response in these ultrasmall volumes. Sigmoidal voltammograms (0.4-2 V/s) are obtained for vial sizes down to 1 pL.

Original language	English (US)
Pages (from-to)	259-263
Number of pages	5
Journal	Analytical Chemistry
Volume	69
Issue number	2
DOIs	https://doi.org/10.1021/ac960559a
State	Published - 1997

All Science Journal Classification (ASJC) codes

Analytical Chemistry

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title = "Electrochemical Analysis in Picoliter Microvials",

abstract = "Lithographically fabricated templates have been used to imprint picoliter to femtoliter microvials in polystyrene. The clear microvials produced in conjunction with a transmission optical microscope and micromanipulators make it possible to handle volumes as small as 1 pL. Voltammetry has been carried out in these well-defined microenvironments with restriction of reagents near the electrode surface. Ferrocenecarboxylic acid has been utilized to characterize the electrochemical response in these ultrasmall volumes. Sigmoidal voltammograms (0.4-2 V/s) are obtained for vial sizes down to 1 pL.",

author = "Clark, {Rose A.} and Hietpas, {Paula Beyer} and Ewing, {Andrew G.}",

year = "1997",

doi = "10.1021/ac960559a",

language = "English (US)",

volume = "69",

pages = "259--263",

journal = "Analytical Chemistry",

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T1 - Electrochemical Analysis in Picoliter Microvials

AU - Clark, Rose A.

AU - Hietpas, Paula Beyer

AU - Ewing, Andrew G.

PY - 1997

Y1 - 1997

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AB - Lithographically fabricated templates have been used to imprint picoliter to femtoliter microvials in polystyrene. The clear microvials produced in conjunction with a transmission optical microscope and micromanipulators make it possible to handle volumes as small as 1 pL. Voltammetry has been carried out in these well-defined microenvironments with restriction of reagents near the electrode surface. Ferrocenecarboxylic acid has been utilized to characterize the electrochemical response in these ultrasmall volumes. Sigmoidal voltammograms (0.4-2 V/s) are obtained for vial sizes down to 1 pL.

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SP - 259

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JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 2

ER -

Electrochemical Analysis in Picoliter Microvials

Abstract

All Science Journal Classification (ASJC) codes

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