TY - JOUR
T1 - Elevated fasting glucose as a potential predictor for asymptomatic cerebral artery stenosis
T2 - A cross-sectional study in Chinese adults
AU - Wang, Jing
AU - Wu, Jianwei
AU - Zhang, Shufeng
AU - Zhang, Liqun
AU - Wang, Chunxue
AU - Gao, Xiang
AU - Zhou, Yong
AU - Wang, Anxin
AU - Wu, Shouling
AU - Zhao, Xingquan
N1 - Publisher Copyright:
© 2014 Elsevier Ireland Ltd.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background and Purpose: Cerebral artery stenosis is known as an important cause of stroke, and elevated fasting glucose level is also considered as a risk factor for stroke. Our aim was to exam whether elevated fasting glucose is associated with cerebral artery stenosis, especially asymptomatic cerebral artery stenosis. Methods: The current study included 5309 participants who were age of 40 years or older, and free of stroke, transient ischemic attack, and coronary artery disease. Cerebral artery stenosis was assessed by Doppler ultrasound. Participants were classified into four subtypes: no cerebral artery stenosis (NCS), intracranial artery stenosis (ICAS), extracranial carotid artery stenosis (ECCS) and combined intracranial artery and extracranial carotid artery stenosis (IECS). Fasting blood glucose concentrations were grouped into: normal fasting glucose (<5.60mmol/l), impaired fasting glucose 1 (IFG1) (5.60-6.09mmol/l), IFG2 (6.10-6.99mmol/l) and diabetes (≥7.00mmol/l). A multinomial logistic regression was used to examine the association between fasting glucose and cerebral artery stenosis, after adjusting for potential confounders. Results: Fasting glucose level was significantly higher in ICAS and IECS groups than the other two groups. In the multinomial logistic regression analysis, IFG2 was the risk factor for ICAS (odds ratio (OR) 1.53, 95% confidential interval (CI), 1.12-2.10), and diabetes was a strong predictor for both ICAS (OR 1.75, 95% CI, 1.38-2.22) and IECS (OR 2.14, 95% CI 1.31-3.49). However, fasting glucose level was not significantly associated with ECCS.
AB - Background and Purpose: Cerebral artery stenosis is known as an important cause of stroke, and elevated fasting glucose level is also considered as a risk factor for stroke. Our aim was to exam whether elevated fasting glucose is associated with cerebral artery stenosis, especially asymptomatic cerebral artery stenosis. Methods: The current study included 5309 participants who were age of 40 years or older, and free of stroke, transient ischemic attack, and coronary artery disease. Cerebral artery stenosis was assessed by Doppler ultrasound. Participants were classified into four subtypes: no cerebral artery stenosis (NCS), intracranial artery stenosis (ICAS), extracranial carotid artery stenosis (ECCS) and combined intracranial artery and extracranial carotid artery stenosis (IECS). Fasting blood glucose concentrations were grouped into: normal fasting glucose (<5.60mmol/l), impaired fasting glucose 1 (IFG1) (5.60-6.09mmol/l), IFG2 (6.10-6.99mmol/l) and diabetes (≥7.00mmol/l). A multinomial logistic regression was used to examine the association between fasting glucose and cerebral artery stenosis, after adjusting for potential confounders. Results: Fasting glucose level was significantly higher in ICAS and IECS groups than the other two groups. In the multinomial logistic regression analysis, IFG2 was the risk factor for ICAS (odds ratio (OR) 1.53, 95% confidential interval (CI), 1.12-2.10), and diabetes was a strong predictor for both ICAS (OR 1.75, 95% CI, 1.38-2.22) and IECS (OR 2.14, 95% CI 1.31-3.49). However, fasting glucose level was not significantly associated with ECCS.
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U2 - 10.1016/j.atherosclerosis.2014.10.083
DO - 10.1016/j.atherosclerosis.2014.10.083
M3 - Article
C2 - 25463102
AN - SCOPUS:84910674572
SN - 0021-9150
VL - 237
SP - 661
EP - 665
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -