TY - JOUR
T1 - Elevated PYY is associated with energy deficiency and indices of subclinical disordered eating in exercising women with hypothalamic amenorrhea
AU - Scheid, Jennifer L.
AU - Williams, Nancy I.
AU - West, Sarah L.
AU - VanHeest, Jaci L.
AU - Souza, Mary Jane De
N1 - Funding Information:
We thank Tanya Burke, Emma O’Donnell, Astrid Bellem, Jason Vescovi, Ph.D. and Susan Awdishu for their important contributions to this research. We thank Oleysa Falenchuk, Ph.D. for statistical advice. We also appreciate the extraordinary cooperation of the study volunteers. We are also very grateful to our sources of support, Arthur Thornton Cardiopulmonary Fund of New Britain General Hospital and the United States Army Medical Research and Material Command Peer Reviewed Medical Research Program (Award Number PR054531). Jennifer L. Scheid is supported by a Canadian Doctoral Scholarship from the Canadian Institutes of Health Research.
PY - 2009/2
Y1 - 2009/2
N2 - The purpose of this study was twofold: (1) to determine if gastrointestinal hormones, associated with energy intake and energy balance, are altered in exercising women with hypothalamic amenorrhea and (2) to assess the association between gastrointestinal hormones and behavioural indicators of subclinical disordered eating in exercising women with hypothalamic amenorrhea. This cross-sectional study analyzed serum ghrelin, peptide YY (PYY), glucagon-like peptide-1 (GLP-1), menstrual status (by E1G and PdG), resting energy expenditure (REE), and subclinical eating behaviours in sedentary ovulatory (SedOv), exercising ovulatory (ExOv), and exercising amenorrheic (ExAmen) women. Groups were similar with respect to age (23.8 ± 0.6 years) and BMI (21.4 ± 0.3 kg/m2). The ratio of REE to predicted REE (REE:predicted REE) was 0.94 ± 0.02, 0.94 ± 0.02, and 0.88 ± 0.02 in the SedOv, ExOv, and ExAmen groups, respectively. The REE:predicted REE in the ExAmen group was consistent with an energy deficiency. LogPYY, ghrelin, dietary cognitive restraint, and drive for thinness were elevated in the ExAmen group compared to other groups. GLP-1 concentrations were similar among groups. LogPYY correlated with drive for thinness and REE/FFM. In conclusion, fasting PYY and ghrelin concentrations are elevated in exercising women with FHA and both gastrointestinal peptides may serve as a proxy indicator of energy deficiency in this population.
AB - The purpose of this study was twofold: (1) to determine if gastrointestinal hormones, associated with energy intake and energy balance, are altered in exercising women with hypothalamic amenorrhea and (2) to assess the association between gastrointestinal hormones and behavioural indicators of subclinical disordered eating in exercising women with hypothalamic amenorrhea. This cross-sectional study analyzed serum ghrelin, peptide YY (PYY), glucagon-like peptide-1 (GLP-1), menstrual status (by E1G and PdG), resting energy expenditure (REE), and subclinical eating behaviours in sedentary ovulatory (SedOv), exercising ovulatory (ExOv), and exercising amenorrheic (ExAmen) women. Groups were similar with respect to age (23.8 ± 0.6 years) and BMI (21.4 ± 0.3 kg/m2). The ratio of REE to predicted REE (REE:predicted REE) was 0.94 ± 0.02, 0.94 ± 0.02, and 0.88 ± 0.02 in the SedOv, ExOv, and ExAmen groups, respectively. The REE:predicted REE in the ExAmen group was consistent with an energy deficiency. LogPYY, ghrelin, dietary cognitive restraint, and drive for thinness were elevated in the ExAmen group compared to other groups. GLP-1 concentrations were similar among groups. LogPYY correlated with drive for thinness and REE/FFM. In conclusion, fasting PYY and ghrelin concentrations are elevated in exercising women with FHA and both gastrointestinal peptides may serve as a proxy indicator of energy deficiency in this population.
UR - https://www.scopus.com/pages/publications/56449119773
UR - https://www.scopus.com/pages/publications/56449119773#tab=citedBy
U2 - 10.1016/j.appet.2008.09.016
DO - 10.1016/j.appet.2008.09.016
M3 - Article
C2 - 18929607
AN - SCOPUS:56449119773
SN - 0195-6663
VL - 52
SP - 184
EP - 192
JO - Appetite
JF - Appetite
IS - 1
ER -