Elevation in Inflammatory Serum Biomarkers Predicts Response to Trastuzumab-Containing Therapy

Ahmed A. Alkhateeb, Kim Leitzel, Suhail M. Ali, Cynthia Campbell-Baird, Matthew Evans, Eva Maria Fuchs, Wolfgang J. Köstler, Allan Lipton, James Connor

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Approximately half of all HER2/neu-overexpressing breast cancer patients do not respond to trastuzumab-containing therapy. Therefore, there remains an urgent and unmet clinical need for the development of predictive biomarkers for trastuzumab response. Recently, several lines of evidence have demonstrated that the inflammatory tumor microenvironment is a major contributor to therapy resistance in breast cancer. In order to explore the predictive value of inflammation in breast cancer patients, we measured the inflammatory biomarkers serum ferritin and C-reactive protein (CRP) in 66 patients immediately before undergoing trastuzumab-containing therapy and evaluated their progression-free and overall survival. The elevation in pre-treatment serum ferritin (>250 ng/ml) or CRP (>7.25 mg/l) was a significant predictor of reduced progression-free survival and shorter overall survival. When patients were stratified based on their serum ferritin and CRP levels, patients with elevation in both inflammatory biomarkers had a markedly poorer response to trastuzumab-containing therapy. Therefore, the elevation in inflammatory serum biomarkers may reflect a pathological state that decreases the clinical efficacy of this therapy. Anti-inflammatory drugs and life-style changes to decrease inflammation in cancer patients should be explored as possible strategies to sensitize patients to anti-cancer therapeutics.

Original languageEnglish (US)
Article numbere51379
JournalPloS one
Issue number12
StatePublished - Dec 29 2012

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'Elevation in Inflammatory Serum Biomarkers Predicts Response to Trastuzumab-Containing Therapy'. Together they form a unique fingerprint.

Cite this