TY - JOUR
T1 - Eligibility for mechanical thrombectomy in acute ischemic stroke
T2 - A phase IV multi-center screening log registry
AU - Tsivgoulis, Georgios
AU - Goyal, Nitin
AU - Mikulik, Robert
AU - Sharma, Vijay K.
AU - Katsanos, Aristeidis H.
AU - Zand, Ramin
AU - Paliwal, Prakash R.
AU - Roussopoulou, Andromachi
AU - Volny, Ondrej
AU - Pandhi, Abhi
AU - Zompola, Christina
AU - Elijovich, Lucas
AU - Safouris, Apostolos
AU - Chang, Jason
AU - Alexandrov, Andrei V.
AU - Alexandrov, Anne W.
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/12/15
Y1 - 2016/12/15
N2 - No eligibility screening logs were kept in recent mechanical thrombectomy (MT) RCTs establishing safety and efficacy of endovascular reperfusion therapies for acute ischemic stroke (AIS). We sought to evaluate the potential eligibility for MT among consecutive AIS patients in a prospective international multicenter study. We prospectively evaluated consecutive AIS patients admitted in four tertiary-care stroke centers during a twelve-month period. Potential eligibility for MT was evaluated using inclusion criteria from MR CLEAN & REVASCAT. Our study population consisted of 1464 AIS patients (mean age 67 ± 14 years, 56% men, median admission NIHSS-score: 5, IQR: 3–10). A total of 123 (8%, 95% CI: 7%–10%) and 82 (6%, 95% CI: 5%–7%) patients fulfilled the inclusion criteria for MR CLEAN&REVASCAT respectively. No evidence of heterogeneity (p > 0.100) was found in the eligibility for MT across the participating centers. Absence of proximal intracranial occlusion (69%) and hospital arrival outside the eligible time window (38% for MR CLEAN & 35% for REVASCAT) were the two most common reasons for ineligibility for MT. Our everyday clinical practice experience suggests that approximately one out of thirteen to seventeen consecutive AIS may be eligible for MT if inclusion criteria for MR CLEAN and REVASCAT are strictly adhered to.
AB - No eligibility screening logs were kept in recent mechanical thrombectomy (MT) RCTs establishing safety and efficacy of endovascular reperfusion therapies for acute ischemic stroke (AIS). We sought to evaluate the potential eligibility for MT among consecutive AIS patients in a prospective international multicenter study. We prospectively evaluated consecutive AIS patients admitted in four tertiary-care stroke centers during a twelve-month period. Potential eligibility for MT was evaluated using inclusion criteria from MR CLEAN & REVASCAT. Our study population consisted of 1464 AIS patients (mean age 67 ± 14 years, 56% men, median admission NIHSS-score: 5, IQR: 3–10). A total of 123 (8%, 95% CI: 7%–10%) and 82 (6%, 95% CI: 5%–7%) patients fulfilled the inclusion criteria for MR CLEAN&REVASCAT respectively. No evidence of heterogeneity (p > 0.100) was found in the eligibility for MT across the participating centers. Absence of proximal intracranial occlusion (69%) and hospital arrival outside the eligible time window (38% for MR CLEAN & 35% for REVASCAT) were the two most common reasons for ineligibility for MT. Our everyday clinical practice experience suggests that approximately one out of thirteen to seventeen consecutive AIS may be eligible for MT if inclusion criteria for MR CLEAN and REVASCAT are strictly adhered to.
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U2 - 10.1016/j.jns.2016.10.018
DO - 10.1016/j.jns.2016.10.018
M3 - Article
C2 - 27871458
AN - SCOPUS:84992530224
SN - 0022-510X
VL - 371
SP - 96
EP - 99
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
ER -