TY - JOUR
T1 - Embracing Complexity
T2 - What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity
AU - Ortigas-Vasquez, Alejandro
AU - Szpara, Moriah
N1 - Publisher Copyright:
Copyright © 2024 by the author(s).
PY - 2024/9/26
Y1 - 2024/9/26
N2 - The arrival of novel sequencing technologies throughout the past two decades has led to a paradigm shift in our understanding of herpesvirus genomic diversity. Previously, herpesviruses were seen as a family of DNA viruses with low genomic diversity. However, a growing body of evidence now suggests that herpesviruses exist as dynamic populations that possess standing variation and evolve at much faster rates than previously assumed. In this review, we explore how strategies such as deep sequencing, long-read sequencing, and haplotype reconstruction are allowing scientists to dissect the genomic composition of herpesvirus populations. We also discuss the challenges that need to be addressed before a detailed picture of herpesvirus diversity can emerge.
AB - The arrival of novel sequencing technologies throughout the past two decades has led to a paradigm shift in our understanding of herpesvirus genomic diversity. Previously, herpesviruses were seen as a family of DNA viruses with low genomic diversity. However, a growing body of evidence now suggests that herpesviruses exist as dynamic populations that possess standing variation and evolve at much faster rates than previously assumed. In this review, we explore how strategies such as deep sequencing, long-read sequencing, and haplotype reconstruction are allowing scientists to dissect the genomic composition of herpesvirus populations. We also discuss the challenges that need to be addressed before a detailed picture of herpesvirus diversity can emerge.
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U2 - 10.1146/annurev-virology-100422-010336
DO - 10.1146/annurev-virology-100422-010336
M3 - Review article
C2 - 38848592
AN - SCOPUS:85202470417
SN - 2327-056X
VL - 11
SP - 67
EP - 87
JO - Annual Review of Virology
JF - Annual Review of Virology
IS - 1
ER -