TY - JOUR
T1 - Emerging applications of bacteria as antitumor agents
AU - Kalia, Vipin Chandra
AU - Patel, Sanjay K.S.
AU - Cho, Byung Kwan
AU - Wood, Thomas K.
AU - Lee, Jung Kul
N1 - Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning ( NRF-2020R1A4A2002854 ). This research was also supported by the Bio & Medical Technology Development Program of the NRF & funded by the Korean government (MSIT) (No. 2021M3A9I5023254 ).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/11
Y1 - 2022/11
N2 - Bacteria are associated with the human body and colonize the gut, skin, and mucous membranes. These associations can be either symbiotic or pathogenic. In either case, bacteria derive more benefit from their host. The ability of bacteria to enter and survive within the human body can be exploited for human benefit. They can be used as a vehicle for delivering or producing bioactive molecules, such as toxins and lytic enzymes, and eventually for killing tumor cells. Clostridium and Salmonella have been shown to infect and survive within the human body, including in tumors. There is a need to develop genetic circuits, which enable bacterial cells to carry out the following activities: (i) escape the human immune system, (ii) invade tumors, (iii) multiply within the tumorous cells, (iv) produce toxins via quorum sensing at low cell densities, and (v) express suicide genes to undergo cell death or cell lysis after the tumor has been lysed. Thus, bacteria have the potential to be exploited as anticancer agents.
AB - Bacteria are associated with the human body and colonize the gut, skin, and mucous membranes. These associations can be either symbiotic or pathogenic. In either case, bacteria derive more benefit from their host. The ability of bacteria to enter and survive within the human body can be exploited for human benefit. They can be used as a vehicle for delivering or producing bioactive molecules, such as toxins and lytic enzymes, and eventually for killing tumor cells. Clostridium and Salmonella have been shown to infect and survive within the human body, including in tumors. There is a need to develop genetic circuits, which enable bacterial cells to carry out the following activities: (i) escape the human immune system, (ii) invade tumors, (iii) multiply within the tumorous cells, (iv) produce toxins via quorum sensing at low cell densities, and (v) express suicide genes to undergo cell death or cell lysis after the tumor has been lysed. Thus, bacteria have the potential to be exploited as anticancer agents.
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U2 - 10.1016/j.semcancer.2021.05.012
DO - 10.1016/j.semcancer.2021.05.012
M3 - Review article
C2 - 33989734
AN - SCOPUS:85106300823
SN - 1044-579X
VL - 86
SP - 1014
EP - 1025
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -