Emerging role of interleukin-22 in autoimmune diseases

Hai Feng Pan; Xiang Pei Li; Song Guo Zheng; Dong Qing Ye

doi:10.1016/j.cytogfr.2012.07.002

Emerging role of interleukin-22 in autoimmune diseases

Hai Feng Pan, Xiang Pei Li, Song Guo Zheng, Dong Qing Ye

Department of Medicine

Research output: Contribution to journal › Short survey › peer-review

91 Scopus citations

Abstract

Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in host defense against Gram-negative bacterial organisms (in gut and lung). Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS) and psoriasis. Therapeutics targeting IL-22 therefore may have promise for treating various autoimmune diseases. In this review, we discuss the recent progression of the involvement of IL-22 in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential.

Original language	English (US)
Pages (from-to)	51-57
Number of pages	7
Journal	Cytokine and Growth Factor Reviews
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.cytogfr.2012.07.002
State	Published - Feb 2013

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cytogfr.2012.07.002

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title = "Emerging role of interleukin-22 in autoimmune diseases",

abstract = "Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in host defense against Gram-negative bacterial organisms (in gut and lung). Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sj{\"o}gren's syndrome (SS) and psoriasis. Therapeutics targeting IL-22 therefore may have promise for treating various autoimmune diseases. In this review, we discuss the recent progression of the involvement of IL-22 in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential.",

author = "Pan, {Hai Feng} and Li, {Xiang Pei} and Zheng, {Song Guo} and Ye, {Dong Qing}",

note = "Funding Information: This work was supported by grants from the National Natural Science Foundation of China ( 81102192 , 30830089 ), the Specialized Research Fund for the Doctoral Program of Higher Education of China ( 20113420120008 ), the Grants for Scientific Research of BSKY (No. XJ201014 ) from Anhui Medical University , as well as grants from the National Institute of Health ( AR059103 and AI084359 ), ACR Within Our Reach Fund, Arthritis Foundation and Wright Foundation . ",

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doi = "10.1016/j.cytogfr.2012.07.002",

language = "English (US)",

volume = "24",

pages = "51--57",

journal = "Cytokine and Growth Factor Reviews",

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T1 - Emerging role of interleukin-22 in autoimmune diseases

AU - Pan, Hai Feng

AU - Li, Xiang Pei

AU - Zheng, Song Guo

AU - Ye, Dong Qing

N1 - Funding Information: This work was supported by grants from the National Natural Science Foundation of China ( 81102192 , 30830089 ), the Specialized Research Fund for the Doctoral Program of Higher Education of China ( 20113420120008 ), the Grants for Scientific Research of BSKY (No. XJ201014 ) from Anhui Medical University , as well as grants from the National Institute of Health ( AR059103 and AI084359 ), ACR Within Our Reach Fund, Arthritis Foundation and Wright Foundation .

PY - 2013/2

Y1 - 2013/2

N2 - Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in host defense against Gram-negative bacterial organisms (in gut and lung). Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS) and psoriasis. Therapeutics targeting IL-22 therefore may have promise for treating various autoimmune diseases. In this review, we discuss the recent progression of the involvement of IL-22 in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential.

AB - Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in host defense against Gram-negative bacterial organisms (in gut and lung). Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS) and psoriasis. Therapeutics targeting IL-22 therefore may have promise for treating various autoimmune diseases. In this review, we discuss the recent progression of the involvement of IL-22 in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential.

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DO - 10.1016/j.cytogfr.2012.07.002

M3 - Short survey

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AN - SCOPUS:84874243953

SN - 1359-6101

VL - 24

SP - 51

EP - 57

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 1

ER -

Emerging role of interleukin-22 in autoimmune diseases

Abstract

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