Emerging treatments for intervertebral disc disease

Gregory D. Arnone, Shivani Rangwala, Ankit I. Mehta

Research output: Chapter in Book/Report/Conference proceedingChapter


Degenerative disc disease (DDD) is a significant component of spine disorders and low back pain, and the prevalence of disc disease is increasing with an aging population. While current treatment modalities, ranging from conservative approaches to surgical interventions, are continually evolving, new therapies for intervertebral disc disease are also in development. Increased research on the cellular mechanisms underlying DDD have led to novel cell-based treatments which aim to delay rates of degeneration [1, 3]. Most of these cellular therapies remain in the research phase. Recent innovations in engineering have also pioneered several types of surgical constructs that improve the durability of treatment, while minimizing device-associated complications. Several examples include hybrid materials for intervertebral cages, zero-profile implants, expandable cages, sagittal correction implants, and disc arthroplasty. Finally, surgical techniques have been refined and adapted to allow less invasive modalities such as endoscopic and percutaneous techniques to reach adequate treatment effect with less risk of adverse event and further degeneration of the incident and adjacent spinal segments. This chapter highlights several emerging non-surgical and surgical treatments for intervertebral disc disease.

Original languageEnglish (US)
Title of host publicationIntervertebral Disc Degeneration
Subtitle of host publicationPrevalence, Risk Factors and Treatments
PublisherNova Science Publishers, Inc.
Number of pages32
ISBN (Electronic)9781634858571
ISBN (Print)9781634858298
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • General Medicine


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