TY - JOUR
T1 - Emotional State Can Affect Inflammatory Responses to Pain Among Rheumatoid Arthritis Patients
T2 - Preliminary Findings
AU - Graham-Engeland, Jennifer E.
AU - Song, Sunmi
AU - Mathur, Ambika
AU - Wagstaff, David A.
AU - Klein, Laura Cousino
AU - Whetzel, Courtney
AU - Ayoub, William T.
N1 - Publisher Copyright:
© The Author(s) 2018.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - In a novel pilot study, we investigated how emotional state is related to inflammatory responses to acute pain among women with rheumatoid arthritis. Nine women completed four 5-hour visits that varied only by manipulation of emotion (anger, sadness, happiness, vs. control); in each visit, acute pain was elicited, with blood draws at baseline, 10 minutes, 60 minutes, and 100 minutes post-pain. We examined the effects of within-subjects factors on circulating inflammatory biomarkers interleukin (IL)-6, IL-10, tumor necrosis factor-α, C-reactive protein, and cortisol. There was a main effect of state anger on IL-6, with higher reported anger associated with higher IL-6 across conditions. Further, there were several interactions between state emotion and condition. For example, when individuals reported higher state anger in the sadness condition compared to their own average, they showed higher levels of IL-6 and cortisol. Findings are discussed within a larger literature suggesting that mixed emotional states can contribute to psychological stress and inflammatory responses.
AB - In a novel pilot study, we investigated how emotional state is related to inflammatory responses to acute pain among women with rheumatoid arthritis. Nine women completed four 5-hour visits that varied only by manipulation of emotion (anger, sadness, happiness, vs. control); in each visit, acute pain was elicited, with blood draws at baseline, 10 minutes, 60 minutes, and 100 minutes post-pain. We examined the effects of within-subjects factors on circulating inflammatory biomarkers interleukin (IL)-6, IL-10, tumor necrosis factor-α, C-reactive protein, and cortisol. There was a main effect of state anger on IL-6, with higher reported anger associated with higher IL-6 across conditions. Further, there were several interactions between state emotion and condition. For example, when individuals reported higher state anger in the sadness condition compared to their own average, they showed higher levels of IL-6 and cortisol. Findings are discussed within a larger literature suggesting that mixed emotional states can contribute to psychological stress and inflammatory responses.
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U2 - 10.1177/0033294118796655
DO - 10.1177/0033294118796655
M3 - Article
C2 - 30189801
AN - SCOPUS:85060534459
SN - 0033-2941
VL - 122
SP - 2026
EP - 2049
JO - Psychological reports
JF - Psychological reports
IS - 6
ER -