Empiric Antimicrobials for Neonatal Sepsis

Olivia B. Payne, Jessica E. Ericson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Neonatal sepsis is a common cause of morbidity and mortality among young infants. Early-onset sepsis occurs in the first 3 days of life and is typically caused by Escherichia coli or group B streptococcus. Late-onset sepsis occurs from days 4 to 30 of life and is most often due to gram-positive organisms. Because the initial presentation of neonatal sepsis is often subtle, antibiotics are usually started empirically while culture results are pending. The choice of empirical antibiotics must balance the potential risks of providing ineffective treatment of the ultimately discovered pathogen with the definite risks of broad-spectrum antibiotic exposure. For most infants, a narrow empirical antibiotic regimen provides effective coverage without undue risk of infection-related morbidity or mortality. However, patient factors and local epidemiology should be considered when making antibiotic choices in order to optimize individual patient outcomes.

Original languageEnglish (US)
Title of host publicationInfectious Disease and Pharmacology
Subtitle of host publicationNeonatology Questions and Controversies
Number of pages11
ISBN (Electronic)9780323543910
ISBN (Print)9780323568562
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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