Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication

Catherine M. Herzog; Fasil Aklilu; Demeke Sibhatu; Dereje Shegu; Redeat Belaineh; Abde Aliy Mohammed; Menbere Kidane; Claudia Schulz; Brian J. Willett; Sarah Cleaveland; Dalan Bailey; Andrew R. Peters; Isabella M. Cattadori; Peter J. Hudson; Hagos Asgedom; Joram Buza; Mesfin Sahle Forza; Tesfaye Rufael Chibssa; Solomon Gebre; Nick Juleff; Ottar N. Bjørnstad; Michael D. Baron; Vivek Kapur

doi:10.1038/s42003-024-06619-2

Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication

Catherine M. Herzog, Fasil Aklilu, Demeke Sibhatu, Dereje Shegu, Redeat Belaineh, Abde Aliy Mohammed, Menbere Kidane, Claudia Schulz, Brian J. Willett, Sarah Cleaveland, Dalan Bailey, Andrew R. Peters, Isabella M. Cattadori, Peter J. Hudson, Hagos Asgedom, Joram Buza, Mesfin Sahle Forza, Tesfaye Rufael Chibssa, Solomon Gebre, Nick JuleffOttar N. Bjørnstad, Michael D. Baron, Vivek Kapur

Research output: Contribution to journal › Article › peer-review

Abstract

Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with local Zebu cattle (Bos taurus indicus) co-housed with goats (Capra aegagrus hircus). Furthermore, we developed a mathematical model to assess the impact of PPRV-transmission from cattle to goats. Of the 32 cattle intranasally infected with the locally endemic lineage IV strain PPRV/Ethiopia/Habru/2014 none transmitted PPRV to 32 co-housed goats. However, these cattle or cattle co-housed with PPRV-infected goats seroconverted. The results confirm previous studies that cattle currently play a negligible role in PPRV-transmission and small ruminant vaccination is sufficient for eradication. However, the possible emergence of PPRV strains more virulent for cattle may impact eradication. Therefore, continued monitoring of PPRV circulation and evolution is recommended.

Original language	English (US)
Article number	937
Journal	Communications Biology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s42003-024-06619-2
State	Published - Dec 2024

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Herzog, C. M., Aklilu, F., Sibhatu, D., Shegu, D., Belaineh, R., Mohammed, A. A., Kidane, M., Schulz, C., Willett, B. J., Cleaveland, S., Bailey, D., Peters, A. R., Cattadori, I. M., Hudson, P. J., Asgedom, H., Buza, J., Forza, M. S., Chibssa, T. R., Gebre, S., ... Kapur, V. (2024). Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication. Communications Biology, 7(1), Article 937. https://doi.org/10.1038/s42003-024-06619-2

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title = "Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication",

abstract = "Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with local Zebu cattle (Bos taurus indicus) co-housed with goats (Capra aegagrus hircus). Furthermore, we developed a mathematical model to assess the impact of PPRV-transmission from cattle to goats. Of the 32 cattle intranasally infected with the locally endemic lineage IV strain PPRV/Ethiopia/Habru/2014 none transmitted PPRV to 32 co-housed goats. However, these cattle or cattle co-housed with PPRV-infected goats seroconverted. The results confirm previous studies that cattle currently play a negligible role in PPRV-transmission and small ruminant vaccination is sufficient for eradication. However, the possible emergence of PPRV strains more virulent for cattle may impact eradication. Therefore, continued monitoring of PPRV circulation and evolution is recommended.",

author = "Herzog, {Catherine M.} and Fasil Aklilu and Demeke Sibhatu and Dereje Shegu and Redeat Belaineh and Mohammed, {Abde Aliy} and Menbere Kidane and Claudia Schulz and Willett, {Brian J.} and Sarah Cleaveland and Dalan Bailey and Peters, {Andrew R.} and Cattadori, {Isabella M.} and Hudson, {Peter J.} and Hagos Asgedom and Joram Buza and Forza, {Mesfin Sahle} and Chibssa, {Tesfaye Rufael} and Solomon Gebre and Nick Juleff and Bj{\o}rnstad, {Ottar N.} and Baron, {Michael D.} and Vivek Kapur",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s42003-024-06619-2",

language = "English (US)",

volume = "7",

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Herzog, CM, Aklilu, F, Sibhatu, D, Shegu, D, Belaineh, R, Mohammed, AA, Kidane, M, Schulz, C, Willett, BJ, Cleaveland, S, Bailey, D, Peters, AR, Cattadori, IM , Hudson, PJ, Asgedom, H, Buza, J, Forza, MS, Chibssa, TR, Gebre, S, Juleff, N, Bjørnstad, ON, Baron, MD & Kapur, V 2024, 'Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication', Communications Biology, vol. 7, no. 1, 937. https://doi.org/10.1038/s42003-024-06619-2

TY - JOUR

T1 - Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication

AU - Herzog, Catherine M.

AU - Aklilu, Fasil

AU - Sibhatu, Demeke

AU - Shegu, Dereje

AU - Belaineh, Redeat

AU - Mohammed, Abde Aliy

AU - Kidane, Menbere

AU - Schulz, Claudia

AU - Willett, Brian J.

AU - Cleaveland, Sarah

AU - Bailey, Dalan

AU - Peters, Andrew R.

AU - Cattadori, Isabella M.

AU - Hudson, Peter J.

AU - Asgedom, Hagos

AU - Buza, Joram

AU - Forza, Mesfin Sahle

AU - Chibssa, Tesfaye Rufael

AU - Gebre, Solomon

AU - Juleff, Nick

AU - Bjørnstad, Ottar N.

AU - Baron, Michael D.

AU - Kapur, Vivek

PY - 2024/12

Y1 - 2024/12

N2 - Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with local Zebu cattle (Bos taurus indicus) co-housed with goats (Capra aegagrus hircus). Furthermore, we developed a mathematical model to assess the impact of PPRV-transmission from cattle to goats. Of the 32 cattle intranasally infected with the locally endemic lineage IV strain PPRV/Ethiopia/Habru/2014 none transmitted PPRV to 32 co-housed goats. However, these cattle or cattle co-housed with PPRV-infected goats seroconverted. The results confirm previous studies that cattle currently play a negligible role in PPRV-transmission and small ruminant vaccination is sufficient for eradication. However, the possible emergence of PPRV strains more virulent for cattle may impact eradication. Therefore, continued monitoring of PPRV circulation and evolution is recommended.

AB - Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with local Zebu cattle (Bos taurus indicus) co-housed with goats (Capra aegagrus hircus). Furthermore, we developed a mathematical model to assess the impact of PPRV-transmission from cattle to goats. Of the 32 cattle intranasally infected with the locally endemic lineage IV strain PPRV/Ethiopia/Habru/2014 none transmitted PPRV to 32 co-housed goats. However, these cattle or cattle co-housed with PPRV-infected goats seroconverted. The results confirm previous studies that cattle currently play a negligible role in PPRV-transmission and small ruminant vaccination is sufficient for eradication. However, the possible emergence of PPRV strains more virulent for cattle may impact eradication. Therefore, continued monitoring of PPRV circulation and evolution is recommended.

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DO - 10.1038/s42003-024-06619-2

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SN - 2399-3642

VL - 7

JO - Communications Biology

JF - Communications Biology

IS - 1

M1 - 937

ER -

Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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