Enantioselective conjugate addition employing 2-heteroaryl titanates and zinc reagents

Anna J. Smith; Lily K. Abbott; Stephen F. Martin

doi:10.1021/ol9013975

Enantioselective conjugate addition employing 2-heteroaryl titanates and zinc reagents

Anna J. Smith
, Lily K. Abbott
, Stephen F. Martin

Penn State Brandywine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A general strategy for the conjugate addition of 2-heteroaryl nucleophiles to cyclic enones, unsaturated lactones, and unsaturated lactams In high enantioselectivities and yields is reported. The use of 2-heteroaryl titanates and zinc reagents offers a practical alternative to 2-heteroarylboronic acids, which are prone to undergo protodeboronatlon

Original language	English (US)
Pages (from-to)	4200-4203
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	18
DOIs	https://doi.org/10.1021/ol9013975
State	Published - Sep 17 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol9013975

Cite this

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title = "Enantioselective conjugate addition employing 2-heteroaryl titanates and zinc reagents",

abstract = "A general strategy for the conjugate addition of 2-heteroaryl nucleophiles to cyclic enones, unsaturated lactones, and unsaturated lactams In high enantioselectivities and yields is reported. The use of 2-heteroaryl titanates and zinc reagents offers a practical alternative to 2-heteroarylboronic acids, which are prone to undergo protodeboronatlon",

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AU - Abbott, Lily K.

AU - Martin, Stephen F.

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N2 - A general strategy for the conjugate addition of 2-heteroaryl nucleophiles to cyclic enones, unsaturated lactones, and unsaturated lactams In high enantioselectivities and yields is reported. The use of 2-heteroaryl titanates and zinc reagents offers a practical alternative to 2-heteroarylboronic acids, which are prone to undergo protodeboronatlon

AB - A general strategy for the conjugate addition of 2-heteroaryl nucleophiles to cyclic enones, unsaturated lactones, and unsaturated lactams In high enantioselectivities and yields is reported. The use of 2-heteroaryl titanates and zinc reagents offers a practical alternative to 2-heteroarylboronic acids, which are prone to undergo protodeboronatlon

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UR - https://www.scopus.com/pages/publications/70349144532#tab=citedBy

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M3 - Article

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EP - 4203

JO - Organic Letters

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Enantioselective conjugate addition employing 2-heteroaryl titanates and zinc reagents

Abstract

All Science Journal Classification (ASJC) codes

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