TY - JOUR
T1 - Endectocides for malaria control
AU - Foy, Brian D.
AU - Kobylinski, Kevin C.
AU - Silva, Ines Marques da
AU - Rasgon, Jason L.
AU - Sylla, Massamba
N1 - Funding Information:
B.D.F., K.C.K., I.M.D.S. and M.S. acknowledge support from National Institutes of Health grant R21 AI079528, Grand Challenges Explorations grant 51995 from the Bill and Melinda Gates Foundation, and CRC grant 1686174 from Colorado State University.
PY - 2011/10
Y1 - 2011/10
N2 - Systemic endectocidal drugs, used to control nematodes in humans and other vertebrates, can be toxic to Anopheles spp. mosquitoes when they take a blood meal from a host that has recently received one of these drugs. Recent laboratory and field studies have highlighted the potential of ivermectin to control malaria parasite transmission if this drug is distributed strategically and more often. There are important theoretical benefits to this strategy, as well as caveats. A better understanding of drug effects against vectors and malaria ecologies are needed. In the near future, ivermectin and other endectocides could serve as potent and novel malaria transmission control tools that are directly linked to the control of neglected tropical diseases in the same communities.
AB - Systemic endectocidal drugs, used to control nematodes in humans and other vertebrates, can be toxic to Anopheles spp. mosquitoes when they take a blood meal from a host that has recently received one of these drugs. Recent laboratory and field studies have highlighted the potential of ivermectin to control malaria parasite transmission if this drug is distributed strategically and more often. There are important theoretical benefits to this strategy, as well as caveats. A better understanding of drug effects against vectors and malaria ecologies are needed. In the near future, ivermectin and other endectocides could serve as potent and novel malaria transmission control tools that are directly linked to the control of neglected tropical diseases in the same communities.
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U2 - 10.1016/j.pt.2011.05.007
DO - 10.1016/j.pt.2011.05.007
M3 - Review article
C2 - 21727027
AN - SCOPUS:80052919214
SN - 1471-4922
VL - 27
SP - 423
EP - 428
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 10
ER -