Endocrinology of male puberty

Katherine Lewis, Peter Lee

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Purpose of review: To review recent information leading to a better understanding of the endocrinology of male puberty, including information from earlier stages of life. Recent findings: Differences in relative levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the neonatal period have been further described, as well as changes in inhibin B and anti-Müllerian hormone levels. Studies among men with congenital hypogonadotropic hypogonadism suggest a role for the 'minipuberty of infancy' in inhibin B levels. Gonadotropin-releasing hormone analog-stimulated LH levels at the age of puberty may be useful in diagnosing hypogonadotropic hypogonadism. Inhibin B levels are likewise useful in monitoring spermatogenic activity. Summary: Data from fetal life (men born small for gestational age with evidence of a defect in steroidogenesis, relatively high LH:FSH ratio among very premature boys), neonatal period (attenuated rise of inhibin B after rFSH stimulation among men with congenital hypogonadotropic hypogonadism), and puberty (often demonstrable by LH levels alone, progressive rise of insulin-like factor 3 levels, and decrease of anti-Müllerian hormone levels as a consequence of FSH and LH stimulation), all enhance the understanding of the physiology of puberty.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Issue number1
StatePublished - Feb 1 2009

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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