Endogenous opiates do not modulate LPS-induced alterations in carbohydrate metabolism.

S. Bundz, P. E. Molina, C. H. Lang, N. N. Abumrad

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4 Scopus citations


This study aimed to determine the contribution of endogenous opiates to the hormonal and glucose metabolic response to lipopolysaccharide (LPS). Rats were infused with naloxone (NAL) (32 micrograms/h) for 2 h prior to the injection of LPS (100 micrograms/100 g body weight) and hemodynamic, hormonal, and metabolic parameters were determined. NAL produced no detectable alterations in any of the parameters assessed. LPS transiently decreases (26%) mean arterial blood pressure (MABP) and increased plasma glucose concentration (100-130%), glucose rate of appearance (50-100%), and glucose rate of disappearance (50-100%). NAL did not alter the LPS-induced drop in mean arterial blood pressure or the glucose response to LPS. LPS reduced plasma insulin (54%), and increased glucagon (270%), corticosterone (180%), and tumor necrosis factor concentrations in plasma (peak 3200-4600 pg/mL at 90 min), with no modification by NAL pretreatment. These results suggest a lack of involvement of endogenous opiate pathways in the glucose metabolic and hormonal responses to LPS.

Original languageEnglish (US)
Pages (from-to)397-402
Number of pages6
JournalShock (Augusta, Ga.)
Issue number6
StatePublished - Dec 1995

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine


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