Endometrial and myometrial prostaglandin release during the menstrual cycle in relation to menstrual blood loss

Margaret C.P. Ress; Anne B.M. Anderson; Laurence M. Demers; A. C. Turnbull

doi:10.1210/jcem-58-5-813

Endometrial and myometrial prostaglandin release during the menstrual cycle in relation to menstrual blood loss

Margaret C.P. Ress, Anne B.M. Anderson, Laurence M. Demers, A. C. Turnbull

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Endometria and myometria were collected at hysterectomy from 42 women with measured menstrual blood loss. Specimens were obtained throughout the menstrual cycle [menstrual (n = 11), follicular (n = 9), early luteal (n = 6), midluteal (n = 9), and late luteal (n = 7)]. In vitro endometrial and myometrial release of prostaglandin F_2α (PGF_2α), PGE₂, and 6-keto-PGF_1α were examined using a superfusiontechnique. In the endometrium, the principal PG produced was PGF_2α, while in th myometrium, it was 6-keto-PGF_la−. Cyclical changes in PG release were found only inthe endometrium, with an increase toward the end of the menstrual cycle and during menstruation. No significant correlation was found between menstrual blood loss (range, 4–840 ml) and PGF_2α, PGE_2α, or 6-keto-PGF_1α release in either endometrium or myometrium. Furthermore, there was no correlation between either the PGF_2α to PGE₂ or the PGF_2α to 6-keto-PGF_2α ratios and menstrual blood loss.

Original language	English (US)
Pages (from-to)	813-818
Number of pages	6
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	58
Issue number	5
DOIs	https://doi.org/10.1210/jcem-58-5-813
State	Published - May 1984

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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title = "Endometrial and myometrial prostaglandin release during the menstrual cycle in relation to menstrual blood loss",

abstract = "Endometria and myometria were collected at hysterectomy from 42 women with measured menstrual blood loss. Specimens were obtained throughout the menstrual cycle [menstrual (n = 11), follicular (n = 9), early luteal (n = 6), midluteal (n = 9), and late luteal (n = 7)]. In vitro endometrial and myometrial release of prostaglandin F2α (PGF2α), PGE2, and 6-keto-PGF1α were examined using a superfusiontechnique. In the endometrium, the principal PG produced was PGF2α, while in th myometrium, it was 6-keto-PGFla−. Cyclical changes in PG release were found only inthe endometrium, with an increase toward the end of the menstrual cycle and during menstruation. No significant correlation was found between menstrual blood loss (range, 4–840 ml) and PGF2α, PGE2α, or 6-keto-PGF1α release in either endometrium or myometrium. Furthermore, there was no correlation between either the PGF2α to PGE2 or the PGF2α to 6-keto-PGF2α ratios and menstrual blood loss.",

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AB - Endometria and myometria were collected at hysterectomy from 42 women with measured menstrual blood loss. Specimens were obtained throughout the menstrual cycle [menstrual (n = 11), follicular (n = 9), early luteal (n = 6), midluteal (n = 9), and late luteal (n = 7)]. In vitro endometrial and myometrial release of prostaglandin F2α (PGF2α), PGE2, and 6-keto-PGF1α were examined using a superfusiontechnique. In the endometrium, the principal PG produced was PGF2α, while in th myometrium, it was 6-keto-PGFla−. Cyclical changes in PG release were found only inthe endometrium, with an increase toward the end of the menstrual cycle and during menstruation. No significant correlation was found between menstrual blood loss (range, 4–840 ml) and PGF2α, PGE2α, or 6-keto-PGF1α release in either endometrium or myometrium. Furthermore, there was no correlation between either the PGF2α to PGE2 or the PGF2α to 6-keto-PGF2α ratios and menstrual blood loss.

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Endometrial and myometrial prostaglandin release during the menstrual cycle in relation to menstrual blood loss

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