Endometrial antibodies versus CA-125 for the detection of endometriosis

R. A. Wild; V. Hirisave; A. Bianco; E. S. Podczaski; L. M. Demers

doi:10.1016/s0015-0282(16)54065-5

Endometrial antibodies versus CA-125 for the detection of endometriosis

R. A. Wild
, V. Hirisave
, A. Bianco
, E. S. Podczaski
, L. M. Demers

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Detection of endometrial antibodies using an indirect immunofluorescence method along with a well-established human endometrial carcinoma cell line was evaluated and compared with CA-125 for detecting endometriosis. Two hundred two patient sera from the infertility, gynecological, and gynecological oncology services were evaluated. The sensitivity for antibody testing was 83.1% with a specificity of 78.8%, in contrast to a sensitivity of 27.3% and a specificity of 82.6% for CA-125. These preliminary findings offer promise that antibody detection methods may be a useful adjunct in the diagnosis of endometriosis.

Original language	English (US)
Pages (from-to)	90-94
Number of pages	5
Journal	Fertility and sterility
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/s0015-0282(16)54065-5
State	Published - 1991

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/s0015-0282(16)54065-5

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@article{c20d49ed7d294e6e9eb906e2f86bb09d,

title = "Endometrial antibodies versus CA-125 for the detection of endometriosis",

abstract = "Detection of endometrial antibodies using an indirect immunofluorescence method along with a well-established human endometrial carcinoma cell line was evaluated and compared with CA-125 for detecting endometriosis. Two hundred two patient sera from the infertility, gynecological, and gynecological oncology services were evaluated. The sensitivity for antibody testing was 83.1\% with a specificity of 78.8\%, in contrast to a sensitivity of 27.3\% and a specificity of 82.6\% for CA-125. These preliminary findings offer promise that antibody detection methods may be a useful adjunct in the diagnosis of endometriosis.",

author = "Wild, \{R. A.\} and V. Hirisave and A. Bianco and Podczaski, \{E. S.\} and Demers, \{L. M.\}",

note = "Funding Information: Received June 5, 1990; revised and accepted August 24, 1990. * Presented at the 45th Annual Meeting of The American Fertility Society, San Francisco, California, November 11 to 16, 1989. t Supported in part by a contract from Winthrop Pharmaceuticals Division of Sterling Drug, New York City, New York. :j: Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center. § Reprint requests: Robert A. Wild, M.D., University of Oklahoma Health Sciences Center, Department of Obstetrics and Gynecology, P.O. Box 26901 4SP720, Oklahoma City, Oklahoma 73190. II Department of Obstetrics and Gynecology, Hershey Medical Center of the Pennsylvania State University. 11 Department of Pathology, Hershey Medical Center of the Pennsylvania State University.",

year = "1991",

doi = "10.1016/s0015-0282(16)54065-5",

language = "English (US)",

volume = "55",

pages = "90--94",

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publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Endometrial antibodies versus CA-125 for the detection of endometriosis

AU - Wild, R. A.

AU - Hirisave, V.

AU - Bianco, A.

AU - Podczaski, E. S.

AU - Demers, L. M.

N1 - Funding Information: Received June 5, 1990; revised and accepted August 24, 1990. * Presented at the 45th Annual Meeting of The American Fertility Society, San Francisco, California, November 11 to 16, 1989. t Supported in part by a contract from Winthrop Pharmaceuticals Division of Sterling Drug, New York City, New York. :j: Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center. § Reprint requests: Robert A. Wild, M.D., University of Oklahoma Health Sciences Center, Department of Obstetrics and Gynecology, P.O. Box 26901 4SP720, Oklahoma City, Oklahoma 73190. II Department of Obstetrics and Gynecology, Hershey Medical Center of the Pennsylvania State University. 11 Department of Pathology, Hershey Medical Center of the Pennsylvania State University.

PY - 1991

Y1 - 1991

N2 - Detection of endometrial antibodies using an indirect immunofluorescence method along with a well-established human endometrial carcinoma cell line was evaluated and compared with CA-125 for detecting endometriosis. Two hundred two patient sera from the infertility, gynecological, and gynecological oncology services were evaluated. The sensitivity for antibody testing was 83.1% with a specificity of 78.8%, in contrast to a sensitivity of 27.3% and a specificity of 82.6% for CA-125. These preliminary findings offer promise that antibody detection methods may be a useful adjunct in the diagnosis of endometriosis.

AB - Detection of endometrial antibodies using an indirect immunofluorescence method along with a well-established human endometrial carcinoma cell line was evaluated and compared with CA-125 for detecting endometriosis. Two hundred two patient sera from the infertility, gynecological, and gynecological oncology services were evaluated. The sensitivity for antibody testing was 83.1% with a specificity of 78.8%, in contrast to a sensitivity of 27.3% and a specificity of 82.6% for CA-125. These preliminary findings offer promise that antibody detection methods may be a useful adjunct in the diagnosis of endometriosis.

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Endometrial antibodies versus CA-125 for the detection of endometriosis

Abstract

All Science Journal Classification (ASJC) codes

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