TY - JOUR
T1 - Endoscopic imaging of cerenkov luminescence
AU - Kothapalli, Sri Rajasekhar
AU - Liu, Hongguang
AU - Liao, Joseph C.
AU - Cheng, Zhen
AU - Gambhir, Sanjiv Sam
PY - 2012/6/1
Y1 - 2012/6/1
N2 - We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical endoscopes, an optical imaging lens system, and a sensitive low-noise charge coupled device (CCD) camera. Our systematic studies using phantom samples show that Cerenkov light from as low as 1 μCi of radioactivity emitted from 18F-Fluorodeoxyglucose (FDG) can be coupled and transmitted through conventional optical fibers and endoscopes. In vivo imaging experiments with tumor bearing mice, intravenously administered with 18F-FDG, further demonstrated that Cerenkov luminescence endoscopy is a promising new tool in the field of endoscopic molecular imaging.
AB - We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical endoscopes, an optical imaging lens system, and a sensitive low-noise charge coupled device (CCD) camera. Our systematic studies using phantom samples show that Cerenkov light from as low as 1 μCi of radioactivity emitted from 18F-Fluorodeoxyglucose (FDG) can be coupled and transmitted through conventional optical fibers and endoscopes. In vivo imaging experiments with tumor bearing mice, intravenously administered with 18F-FDG, further demonstrated that Cerenkov luminescence endoscopy is a promising new tool in the field of endoscopic molecular imaging.
UR - http://www.scopus.com/inward/record.url?scp=84863974459&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863974459&partnerID=8YFLogxK
U2 - 10.1364/BOE.3.001215
DO - 10.1364/BOE.3.001215
M3 - Article
C2 - 22741069
AN - SCOPUS:84863974459
SN - 2156-7085
VL - 3
SP - 1215
EP - 1225
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 6
ER -