Endoscopic imaging of cerenkov luminescence

Sri Rajasekhar Kothapalli, Hongguang Liu, Joseph C. Liao, Zhen Cheng, Sanjiv Sam Gambhir

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical endoscopes, an optical imaging lens system, and a sensitive low-noise charge coupled device (CCD) camera. Our systematic studies using phantom samples show that Cerenkov light from as low as 1 μCi of radioactivity emitted from 18F-Fluorodeoxyglucose (FDG) can be coupled and transmitted through conventional optical fibers and endoscopes. In vivo imaging experiments with tumor bearing mice, intravenously administered with 18F-FDG, further demonstrated that Cerenkov luminescence endoscopy is a promising new tool in the field of endoscopic molecular imaging.

Original languageEnglish (US)
Pages (from-to)1215-1225
Number of pages11
JournalBiomedical Optics Express
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2012

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Fingerprint

Dive into the research topics of 'Endoscopic imaging of cerenkov luminescence'. Together they form a unique fingerprint.

Cite this