TY - JOUR
T1 - Endothelial-dependent flow-mediated dilation in african americans with masked-hypertension
AU - Veerabhadrappa, Praveen
AU - Diaz, Keith M.
AU - Feairheller, Deborah L.
AU - Sturgeon, Katie M.
AU - Williamson, Sheara T.
AU - Crabbe, Deborah L.
AU - Kashem, Abul M.
AU - Brown, Michael D.
N1 - Funding Information:
Acknowledgment:this research was supported by NIH/NHLbI Grant rO1 HL085497 (PI, Michael brown) and by NIH/NIA Grant KO1 AG019640 (PI, Michael brown).the abstract was presented at the American Heart Association, Scientific Sessions 2010.
PY - 2011/10
Y1 - 2011/10
N2 - BackgroundOffice-blood pressure (BP) measurements alone overlook a significant number of individuals with masked-hypertension (office-BP: 120/80-139/89mmHg and 24-h ambulatory BP monitoring (ABPM) daytime 135/85mmHg or night-time 120/70mmHg). Diminished endothelial function contributes to the pathogenesis of hypertension. To better understand the pathophysiology involved in the increased cardiovascular (CV) disease risk associated with masked-hypertension, we estimated the occurrence, assessed the endothelial function, compared plasma levels of inflammatory markers, white blood cell count (WBC count), tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (hsCRP) and examined the possible relationship between endothelial function and inflammatory markers in apparently healthy prehypertensive (office-BP: 120/80-139/89mmHg) African Americans.MethodsFifty African Americans who were sedentary, nondiabetic, nonsmoking, devoid of CV disease were recruited. Office-BP was measured according to JNC-7 guidelines to identify prehypertensives in whom ABPM was then assessed. Fasting plasma samples were assayed for inflammatory markers. Brachial artery flow-mediated dilation (FMD) at rest and during reactive hyperemia was measured in a subset of prehypertensives.ResultsSubjects in the masked-hypertension sub-group had a higher hsCRP (P = 0.04) and diminished endothelial function (P = 0.03) compared to the true-prehypertensive sub-group (office-BP: 120/80-139/89mmHg and ABPM: daytime 135/85mmHg or night-time 120/70mmHg). Regression analysis showed that endothelial function was inversely related to hsCRP amongst the masked-hypertensive sub-group (R 2 = 0.160; P = 0.04).ConclusionsMasked- hypertension was identified in 58% of African Americans which suggests that a masking phenomenon may exist in a sub-group of prehypertensives who also seem to have a diminished endothelial function that could be mediated by an elevated subclinical inflammation leading to the increased CV disease.
AB - BackgroundOffice-blood pressure (BP) measurements alone overlook a significant number of individuals with masked-hypertension (office-BP: 120/80-139/89mmHg and 24-h ambulatory BP monitoring (ABPM) daytime 135/85mmHg or night-time 120/70mmHg). Diminished endothelial function contributes to the pathogenesis of hypertension. To better understand the pathophysiology involved in the increased cardiovascular (CV) disease risk associated with masked-hypertension, we estimated the occurrence, assessed the endothelial function, compared plasma levels of inflammatory markers, white blood cell count (WBC count), tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (hsCRP) and examined the possible relationship between endothelial function and inflammatory markers in apparently healthy prehypertensive (office-BP: 120/80-139/89mmHg) African Americans.MethodsFifty African Americans who were sedentary, nondiabetic, nonsmoking, devoid of CV disease were recruited. Office-BP was measured according to JNC-7 guidelines to identify prehypertensives in whom ABPM was then assessed. Fasting plasma samples were assayed for inflammatory markers. Brachial artery flow-mediated dilation (FMD) at rest and during reactive hyperemia was measured in a subset of prehypertensives.ResultsSubjects in the masked-hypertension sub-group had a higher hsCRP (P = 0.04) and diminished endothelial function (P = 0.03) compared to the true-prehypertensive sub-group (office-BP: 120/80-139/89mmHg and ABPM: daytime 135/85mmHg or night-time 120/70mmHg). Regression analysis showed that endothelial function was inversely related to hsCRP amongst the masked-hypertensive sub-group (R 2 = 0.160; P = 0.04).ConclusionsMasked- hypertension was identified in 58% of African Americans which suggests that a masking phenomenon may exist in a sub-group of prehypertensives who also seem to have a diminished endothelial function that could be mediated by an elevated subclinical inflammation leading to the increased CV disease.
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U2 - 10.1038/ajh.2011.103
DO - 10.1038/ajh.2011.103
M3 - Article
C2 - 21677701
AN - SCOPUS:80052965912
SN - 0895-7061
VL - 24
SP - 1102
EP - 1107
JO - American journal of hypertension
JF - American journal of hypertension
IS - 10
ER -