Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle

Keyphrases

• Signaling Pathway 100%
• Mammalian Target of Rapamycin (mTOR) 100%
• S6 Kinase 1 (S6K1) 100%
• Phosphorylation 100%
• 4E-BP1 100%
• Skeletal muscle 100%
• Endotoxin 100%
• Leucine 100%
• Lipopolysaccharide 90%
• Eukaryotic Translation Initiation Factor 4E (eIF4E) 27%
• Amino Acids 18%
• Growth Factors 18%
• Insulin-like 18%
• Protein Synthesis 18%
• Plasma Concentration 18%
• Lipopolysaccharide-induced 18%
• Insulin 9%
• Between-group 9%
• Gastrocnemius 9%
• Translational Control 9%
• Basal Level 9%
• Orally Administered 9%
• Skeletal muscle Protein Synthesis 9%
• Signal Component 9%
• Anabolic Effect 9%
• I to 9%
• RPS6 9%
• RU486 9%
• Glucocorticoid Receptor Antagonist 9%
• Tuberous Sclerosis Complex 9%
• Total Amino Acids 9%
• Anabolic Response 9%

Biochemistry, Genetics and Molecular Biology

• Skeletal Muscle 100%
• Mammalian Target of Rapamycin 100%
• Leucine 100%
• Lipopolysaccharide 100%
• Amino Acids 25%
• Protein Biosynthesis 25%
• Blood Level 16%
• Insulin-Like Growth Factor 1 16%
• Ribosomal Protein S6 8%
• Eukaryotic Initiation Factor 8%
• Glucocorticoid Receptor 8%
• Insulin Blood Level 8%
• Receptor Antagonist 8%
• TSC2 8%