TY - JOUR
T1 - Endovascular coil embolization of intracranial aneurysms
T2 - Important factors related to rates and outcomes of incomplete occlusion
AU - Kole, Max K.
AU - Pelz, David M.
AU - Kalapos, Paul
AU - Lee, Donald H.
AU - Gulka, Irene B.
AU - Lownie, Stephen P.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2005/4
Y1 - 2005/4
N2 - Object. The authors report on important factors that influenced clinical and angiographically demonstrated outcomes in patients treated using coil embolization. Methods. This study included 160 consecutive patients who underwent endovascular coil embolization for treatment of intracranial aneurysms. Univariate and multivariate logistic regression analyses were performed to assess factors that influenced the immediate posttreatment angiographic result. Cox regression analysis was used to establish factors related to the occurrence of negative events as well as a curve indicating the time to a negative event. Negative events were defined as aneurysm remnant increase, repeated treatment, rebleeding, or death during periprocedural hospitalization. Seventy-three percent of the patients treated in this study were independent or demonstrated no deficit (Glasgow Outcome Scale [GOS] Score 4 or 5) at a mean follow up of 18.2 months. The annual delayed rebleeding rate was 0.45%. Fifty percent of patients (65 of 131) suffered a negative event within 13 6 14 months (standard deviation). Statistically significant factors associated with the occurrence of negative events were rupture status (p = 0.0128) and immediate posttreatment angiographic result (p , 0.001). Overall clinical outcome assessed using the GOS was significantly related to the immediate posttreatment angiographic result (x2 = 4.788, p = 0.029). The immediate posttreatment angiographic results were significantly influenced by catheter stability (p = 0.0012), aneurysm geometry (that is, simple or complex, p = 0.0053), and aneurysm neck diameter (p = 0.0205). Conclusions. A good or excellent clinical outcome can be obtained in most patients treated using endovascular coil embolization of intracranial aneurysms. Note, however, that a significant number of patients treated using traditional platinum coils will harbor unstable aneurysm remnants or require repeated treatment.
AB - Object. The authors report on important factors that influenced clinical and angiographically demonstrated outcomes in patients treated using coil embolization. Methods. This study included 160 consecutive patients who underwent endovascular coil embolization for treatment of intracranial aneurysms. Univariate and multivariate logistic regression analyses were performed to assess factors that influenced the immediate posttreatment angiographic result. Cox regression analysis was used to establish factors related to the occurrence of negative events as well as a curve indicating the time to a negative event. Negative events were defined as aneurysm remnant increase, repeated treatment, rebleeding, or death during periprocedural hospitalization. Seventy-three percent of the patients treated in this study were independent or demonstrated no deficit (Glasgow Outcome Scale [GOS] Score 4 or 5) at a mean follow up of 18.2 months. The annual delayed rebleeding rate was 0.45%. Fifty percent of patients (65 of 131) suffered a negative event within 13 6 14 months (standard deviation). Statistically significant factors associated with the occurrence of negative events were rupture status (p = 0.0128) and immediate posttreatment angiographic result (p , 0.001). Overall clinical outcome assessed using the GOS was significantly related to the immediate posttreatment angiographic result (x2 = 4.788, p = 0.029). The immediate posttreatment angiographic results were significantly influenced by catheter stability (p = 0.0012), aneurysm geometry (that is, simple or complex, p = 0.0053), and aneurysm neck diameter (p = 0.0205). Conclusions. A good or excellent clinical outcome can be obtained in most patients treated using endovascular coil embolization of intracranial aneurysms. Note, however, that a significant number of patients treated using traditional platinum coils will harbor unstable aneurysm remnants or require repeated treatment.
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U2 - 10.3171/jns.2005.102.4.0607
DO - 10.3171/jns.2005.102.4.0607
M3 - Article
C2 - 15871501
AN - SCOPUS:18744389487
SN - 0022-3085
VL - 102
SP - 607
EP - 615
JO - Journal of neurosurgery
JF - Journal of neurosurgery
IS - 4
ER -