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Engrailed (Gln50→Lys) homeodomain-DNA complex at 1.9 Å resolution: Structural basis for enhanced affinity and altered specificity
Lisa Tucker-Kellogg
, Mark A. Rould
, Kristen A. Chambers
, Sarah E. Ades
, Robert T. Sauer
, Carl O. Pabo
Biochemistry & Molecular Biology
Research output
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Contribution to journal
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Article
›
peer-review
92
Scopus citations
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Dive into the research topics of 'Engrailed (Gln50→Lys) homeodomain-DNA complex at 1.9 Å resolution: Structural basis for enhanced affinity and altered specificity'. Together they form a unique fingerprint.
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Keyphrases
Homeodomain
100%
DNA Complex
100%
Engrailed
100%
Altered Specificity
100%
Binding Site
50%
Hydrogen Bonds (H-bonds)
50%
Guanine
50%
Side Chain
33%
Mediated Interaction
33%
Thymine
16%
High-resolution Structures
16%
Lysine
16%
Water Molecule
16%
Major Groove
16%
Gene Regulation
16%
Overall Structure
16%
Role of Water
16%
DNA Motif
16%
Eukaryotic Genes
16%
Homeodomain Proteins
16%
DNA Recognition
16%
DNA-binding Specificity
16%
Biochemistry, Genetics and Molecular Biology
Homeodomain
100%
Binding Site
42%
Hydrogen Bond
42%
Guanine
42%
Wild Type
28%
Conformation
14%
Crystal Structure
14%
DNA Binding
14%
Lysine
14%
Gene Control
14%
DNA Binding Domain
14%
Homeodomain Protein
14%
Thymine
14%