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Enhanced immune response in the urinary tract of the rat following vaginal immunization

  • J. Jensen
  • , D. T. Uehling
  • , K. Kim
  • , K. Seagren-Rasmussen
  • , E. Balish

Research output: Contribution to journalArticlepeer-review

Abstract

The immune response in the rat urinary tract was assessed by an enzyme-linked immunosorbent assay for immunoglobulins following vaginal immunization and subsequent intravesical challenge with live E. coli 06. Vaginally immunized rats showed a strong and rapid bladder immune resonse following intravesical challenge, in contrast to nonimmunized control rats. The immune response was localized to the urinary tract in that antibody to E. coli 06 was not detected in serum, saliva and vaginal washes from immunized rats.

Original languageEnglish (US)
Pages (from-to)164-166
Number of pages3
JournalJournal of Urology
Volume132
Issue number1
DOIs
StatePublished - 1984

All Science Journal Classification (ASJC) codes

  • Urology

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