Enzyme-Compatible Dynamic Nanoreactors from Electrostatically Bridged Like-Charged Surfactants and Polyelectrolytes

Martin J. Thiele; Mehdi D. Davari; Isabell Hofmann; Melanie König; Carlos G. Lopez; Ljubica Vojcic; Walter Richtering; Ulrich Schwaneberg; Larisa A. Tsarkova

doi:10.1002/anie.201805021

Enzyme-Compatible Dynamic Nanoreactors from Electrostatically Bridged Like-Charged Surfactants and Polyelectrolytes

Martin J. Thiele
, Mehdi D. Davari
, Isabell Hofmann
, Melanie König
, Carlos G. Lopez
, Ljubica Vojcic
, Walter Richtering
, Ulrich Schwaneberg
, Larisa A. Tsarkova

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Reported is an unanticipated mechanism of attractive electrostatic interactions of fully neutralized polyacrylic acid (PAA) with like-charged surfactants. Amphiphilic polymer-surfactant complexes with high interfacial activity and a solubilization capacity exceeding that of conventional micelles are formed by bridging with Ca²⁺ ions. Incorporation of a protease into such dynamic nanoreactors results in a synergistically enhanced cleaning performance because of the improved solubilization of poorly water-soluble immobilized proteins. Competitive interfacial and intermolecular interactions on different time- and length-scales have been resolved using colorimetric analysis, dynamic tensiometry, light scattering, and molecular dynamic simulations. The discovered bridging association mechanism suggests reengineering of surfactant/polymer/enzyme formulations of modern detergents and opens new opportunities in advancing labile delivery systems.

Original language	English (US)
Pages (from-to)	9402-9407
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	30
DOIs	https://doi.org/10.1002/anie.201805021
State	Published - Jul 20 2018

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

Access to Document

10.1002/anie.201805021

Cite this

@article{ac027379efe1450e83b75eb1f6274a79,

title = "Enzyme-Compatible Dynamic Nanoreactors from Electrostatically Bridged Like-Charged Surfactants and Polyelectrolytes",

abstract = "Reported is an unanticipated mechanism of attractive electrostatic interactions of fully neutralized polyacrylic acid (PAA) with like-charged surfactants. Amphiphilic polymer-surfactant complexes with high interfacial activity and a solubilization capacity exceeding that of conventional micelles are formed by bridging with Ca2+ ions. Incorporation of a protease into such dynamic nanoreactors results in a synergistically enhanced cleaning performance because of the improved solubilization of poorly water-soluble immobilized proteins. Competitive interfacial and intermolecular interactions on different time- and length-scales have been resolved using colorimetric analysis, dynamic tensiometry, light scattering, and molecular dynamic simulations. The discovered bridging association mechanism suggests reengineering of surfactant/polymer/enzyme formulations of modern detergents and opens new opportunities in advancing labile delivery systems.",

author = "Thiele, \{Martin J.\} and Davari, \{Mehdi D.\} and Isabell Hofmann and Melanie K{\"o}nig and Lopez, \{Carlos G.\} and Ljubica Vojcic and Walter Richtering and Ulrich Schwaneberg and Tsarkova, \{Larisa A.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = jul,

day = "20",

doi = "10.1002/anie.201805021",

language = "English (US)",

volume = "57",

pages = "9402--9407",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "30",

}

TY - JOUR

T1 - Enzyme-Compatible Dynamic Nanoreactors from Electrostatically Bridged Like-Charged Surfactants and Polyelectrolytes

AU - Thiele, Martin J.

AU - Davari, Mehdi D.

AU - Hofmann, Isabell

AU - König, Melanie

AU - Lopez, Carlos G.

AU - Vojcic, Ljubica

AU - Richtering, Walter

AU - Schwaneberg, Ulrich

AU - Tsarkova, Larisa A.

PY - 2018/7/20

Y1 - 2018/7/20

N2 - Reported is an unanticipated mechanism of attractive electrostatic interactions of fully neutralized polyacrylic acid (PAA) with like-charged surfactants. Amphiphilic polymer-surfactant complexes with high interfacial activity and a solubilization capacity exceeding that of conventional micelles are formed by bridging with Ca2+ ions. Incorporation of a protease into such dynamic nanoreactors results in a synergistically enhanced cleaning performance because of the improved solubilization of poorly water-soluble immobilized proteins. Competitive interfacial and intermolecular interactions on different time- and length-scales have been resolved using colorimetric analysis, dynamic tensiometry, light scattering, and molecular dynamic simulations. The discovered bridging association mechanism suggests reengineering of surfactant/polymer/enzyme formulations of modern detergents and opens new opportunities in advancing labile delivery systems.

AB - Reported is an unanticipated mechanism of attractive electrostatic interactions of fully neutralized polyacrylic acid (PAA) with like-charged surfactants. Amphiphilic polymer-surfactant complexes with high interfacial activity and a solubilization capacity exceeding that of conventional micelles are formed by bridging with Ca2+ ions. Incorporation of a protease into such dynamic nanoreactors results in a synergistically enhanced cleaning performance because of the improved solubilization of poorly water-soluble immobilized proteins. Competitive interfacial and intermolecular interactions on different time- and length-scales have been resolved using colorimetric analysis, dynamic tensiometry, light scattering, and molecular dynamic simulations. The discovered bridging association mechanism suggests reengineering of surfactant/polymer/enzyme formulations of modern detergents and opens new opportunities in advancing labile delivery systems.

UR - https://www.scopus.com/pages/publications/85050027521

UR - https://www.scopus.com/pages/publications/85050027521#tab=citedBy

U2 - 10.1002/anie.201805021

DO - 10.1002/anie.201805021

M3 - Article

C2 - 29889346

AN - SCOPUS:85050027521

SN - 1433-7851

VL - 57

SP - 9402

EP - 9407

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 30

ER -

Enzyme-Compatible Dynamic Nanoreactors from Electrostatically Bridged Like-Charged Surfactants and Polyelectrolytes

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this