Epidemiology and clinical characteristics of COVID- 19 patients requiring critical care in a Tertiary care teaching hospital

Rupavath Ramkumar, Deepa Rani, Sulagna Bhattacharjee, Richa Aggarwal, Kapil Dev Soni, Ajisha Aravindan, Anju Gupta, Arshad Ayub, Kelika Prakash, Venkata Ganesh, Anjan Trikha

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Abstract

Background and Aims: We describe the epidemiological and clinical characteristics, and 28 day outcome of critically ill COVID-19 patients admitted to a tertiary care centre in India. Material and Methods: We included 60 adult critically ill COVID-19 patients in this prospective observational study, admitted to the intensive care unit (ICU) after obtaining ethics committee approval and informed consent. Demographics, clinical data, and treatment outcome at 28 days were assessed. Results: Demographic characteristics of the COVID-19 patients reveal that compared to the survivors, the non-survivors were significantly older [57.5 vs. 47.5 years], had more comorbid disease [Charlson's comorbidity index 4 vs. 2], higher Apache II scores [19 vs. 8.5], and had significantly higher percentage of smokers. Diabetes mellitus and hypertension were the most common comorbidities. Dyspnea, fever, and cough were the most common presenting symptoms. Total leucocyte count as well as blood lactate level were significantly higher in non-survivors. Around 47% patients had severe ARDS, and 60% patients required invasive mechanical ventilation. 28 day ICU mortality was 50%, with a mortality of 75% in patients receiving invasive mechanical ventilation. Mortality was higher in males than females (57% vs. 33%). Acute kidney injury and septic shock were the most common non-pulmonary complications during ICU stay. Incidence of liver dysfunction, septic shock, and vasopressor use was significantly higher in the non-survivors. Conclusion: This study demonstrates a high 28 day mortality in severe COVID-19 patients. Further well designed prospective studies with larger sample size are needed to identify the risk factors associated with poor outcome in such patients.

Original languageEnglish (US)
Pages (from-to)366-370
Number of pages5
JournalJournal of Anaesthesiology Clinical Pharmacology
Volume37
Issue number3
DOIs
StatePublished - Jul 1 2021

All Science Journal Classification (ASJC) codes

  • General Pharmacology, Toxicology and Pharmaceutics
  • Anesthesiology and Pain Medicine
  • Pharmacology (medical)

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