Epidermal growth factor enhances spontaneous sleep in rabbits

Tetsuya Kushikata, Jidong Fang, Zutang Chen, Ying Wang, James M. Krueger

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47 Scopus citations


Several growth factors are implicated in sleep regulation. Epidermal growth factor (EGF) is found in the brain, and it influences the production of several sleep-promoting substances. We determined, therefore, whether administration of exogenous EGF affected spontaneous sleep in rabbits. Twenty-five rabbits were implanted with electroencephalographic electrodes, a brain thermistor, and an intracerebroventricular guide cannula. Three doses of EGF (0.5, 5, and 25 μg) were used. The animals were injected intracerebroventricularly with saline as control and one dose of EGF on 2 separate days. Five and twenty-five micrograms of EGF enhanced non-rapid eye movement sleep and increased brain temperature. The 25-μg dose of EGF also inhibited rapid eye movement sleep across the 23-h postinjection recording period. Results are consistent with the hypothesis that EGF, like other growth factors, could be involved in sleep regulation.

Original languageEnglish (US)
Pages (from-to)R509-R514
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number2 44-2
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • General Medicine


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