TY - JOUR
T1 - Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
AU - Kwapis, Janine L.
AU - Alaghband, Yasaman
AU - Kramár, Enikö A.
AU - López, Alberto J.
AU - Vogel Ciernia, Annie
AU - White, André O.
AU - Shu, Guanhua
AU - Rhee, Diane
AU - Michael, Christina M.
AU - Montellier, Emilie
AU - Liu, Yu
AU - Magnan, Christophe N.
AU - Chen, Siwei
AU - Sassone-Corsi, Paolo
AU - Baldi, Pierre
AU - Matheos, Dina P.
AU - Wood, Marcelo A.
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired hippocampal memory. Here, we show that the repressive histone deacetylase HDAC3 restricts long-term memory, synaptic plasticity, and experience-induced expression of the circadian gene Per1 in the aging hippocampus without affecting rhythmic circadian activity patterns. We also demonstrate that hippocampal Per1 is critical for long-term memory formation. Together, our data challenge the traditional idea that alterations in the core circadian clock drive circadian-related changes in memory formation and instead argue for a more autonomous role for circadian clock gene function in hippocampal cells to gate the likelihood of long-term memory formation.
AB - Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired hippocampal memory. Here, we show that the repressive histone deacetylase HDAC3 restricts long-term memory, synaptic plasticity, and experience-induced expression of the circadian gene Per1 in the aging hippocampus without affecting rhythmic circadian activity patterns. We also demonstrate that hippocampal Per1 is critical for long-term memory formation. Together, our data challenge the traditional idea that alterations in the core circadian clock drive circadian-related changes in memory formation and instead argue for a more autonomous role for circadian clock gene function in hippocampal cells to gate the likelihood of long-term memory formation.
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U2 - 10.1038/s41467-018-05868-0
DO - 10.1038/s41467-018-05868-0
M3 - Article
C2 - 30127461
AN - SCOPUS:85051860557
SN - 2041-1723
VL - 9
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 3323
ER -