TY - JOUR
T1 - Epinephrine is associated with both erectile dysfunction and lower urinary tract symptoms
AU - Trussell, J. C.
AU - Kunselman, Allen
AU - Legro, Richard
N1 - Funding Information:
Supported by National Institutes of Health grant K24 KD01476.
Funding Information:
R.S.L. has received research grants from Solvay Pharmaceuticals and honoraria from GlaxoSmithKline, and has served as a speaker for HRA Pharma, Serono, Biosympsia, and Organon. J.C.T. has nothing to disclose. A.R.K. has nothing to disclose.
PY - 2010/2
Y1 - 2010/2
N2 - Objective: To determine whether patients with erectile dysfunction (ED) have a higher incidence of insulin resistance (IR) when compared with controls. Design: Prospective case-control study. Setting: Academic medical center. Patient(s): Twenty-nine nondiabetic men aged 18-66 years were enrolled. Of these, 28 completed the study: 17 had ED, and 11 did not. Intervention(s): Validated ED questionnaires, examination, serum hormones evaluation, and oral glucose tolerance testing. Main Outcome Measure(s): Association of IR with ED. Result(s): The association between worsening degrees of both lower urinary tract symptoms (LUTS) and ED was reaffirmed, as was a potential correlation between the two-epinephrine. There was a negative association between serum levels of epinephrine and scores on the 5-item version of the International Index of Erectile Dysfunction for ED (Spearman correlation coefficient = -0.38). On the other hand, men with ED were not more likely to have IR compared with controls. Conclusion(s): Epinephrine may be the common link between ED and LUTS.
AB - Objective: To determine whether patients with erectile dysfunction (ED) have a higher incidence of insulin resistance (IR) when compared with controls. Design: Prospective case-control study. Setting: Academic medical center. Patient(s): Twenty-nine nondiabetic men aged 18-66 years were enrolled. Of these, 28 completed the study: 17 had ED, and 11 did not. Intervention(s): Validated ED questionnaires, examination, serum hormones evaluation, and oral glucose tolerance testing. Main Outcome Measure(s): Association of IR with ED. Result(s): The association between worsening degrees of both lower urinary tract symptoms (LUTS) and ED was reaffirmed, as was a potential correlation between the two-epinephrine. There was a negative association between serum levels of epinephrine and scores on the 5-item version of the International Index of Erectile Dysfunction for ED (Spearman correlation coefficient = -0.38). On the other hand, men with ED were not more likely to have IR compared with controls. Conclusion(s): Epinephrine may be the common link between ED and LUTS.
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U2 - 10.1016/j.fertnstert.2008.10.034
DO - 10.1016/j.fertnstert.2008.10.034
M3 - Article
C2 - 19062003
AN - SCOPUS:75749137797
SN - 0015-0282
VL - 93
SP - 837
EP - 842
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3
ER -